Buckle up! We're in for a wild ride today. A new Nature Metabolism paper by scientists from China adds a surprising twist to the long-known FTO GWAS story. The FTO locus (16q12.2) is the first ever GWAS locus to be associated with obesity and even after 16 yrs now, scientists

👏 Check out all the ARPA-H news, including information about THOR, here! arpa-h.gov/news/

“But I learned so much from the zig zag” - Katalin Kariko on her untraditional career path

Our article is now live at Nature Cell Biology! representing a fantastic collaboration with D. Allan Drummond and squire lab. We demonstrated reversible storage of stress-induced orphan ribosomal proteins within chaperone-stirred liquid condensates. Dive in nature.com/articles/s4155…

Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR go.nature.com/3NMGcyO

Really wild and cool discovery for virus nerds: an entirely new class of viroids found by Stanford's Andrew Fire and colleagues, in a search of human oral microbiomes. They encode a new class of proteins as well: biorxiv.org/content/10.110…

New preprint! Ben Adler and I @doudna_lab, in collaboration with Emily Armbruster and @JoePogliano, unveil a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. College of Chemistry @igisci HHMI biorxiv.org/content/10.110… 🧵 1/14

We know the importance of subtle gene dosage variation, and yet the main tool of molbio is gene KO/KD. In our new preprint, Júlia Domingo introduced subtle modulations of transcription factor dosage by CRISPRi/a, and quantified responses by scRNA-seq. 1/ biorxiv.org/content/10.110…

So excited to share our preprint from the El-Samad lab on engineering multiple small molecule and cell contact-inducible systems for controlling gene expression and differentiation in mESCs! biorxiv.org/content/10.110…

All these findings are perfectly in line with theory suggesting that cooperativity of transcriptional regulators is not only crucial for cell fate decisions, but at the same time makes them extremely dosage-sensitive. #haploinsufficiency 3/3 journals.biologists.com/bio/article/11…

To the top of the reading list! Some intriguing ideas and observations on modes and tuning of epigenetic memory. biorxiv.org/content/10.110…

It's new-preprint-from-the-lab day! (In my opinion the most fun + authentic day to celebrate a new publication.) Check it out: "Large-scale control over collective cell migration using light-controlled epidermal growth factor receptors" biorxiv.org/content/10.110…

Today in Nature Biotechnology, we describe first-gen click editors (CEs), which couple the advantageous properties of DNA-dependent DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise and versatile human genome editing. 🧬 nature.com/articles/s4158…

Epigenome editing technologies for discovery and medicine go.nature.com/4cXw54M

🚨 New preprint alert! I am excited to present a collaboration between the Doudna Lab and Zev Bryant lab, with co-first authors Noor Al-Sayyad and Kevin Wasko and me. Curious about what drives high-efficiency genome editing by Cas9? Let’s dive in!👇🧵biorxiv.org/content/10.110…

Excited to share our new paper where we explore why dCas9-KRAB protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. biorxiv.org/content/10.110…

Interested in pursuing a PhD to explore the world of RNA granules and phase separation? Labpage: sites.google.com/view/boselab Apply for the IIT PhD programme by Nov 2, 2024 iitkgp.ac.in/phd-admission

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…

Preprint: siTNK cells, as hPSC-derived hybrid cells with dual features of adaptive T and inherent NK cells, offer an artificial cell source for human immunotherapies biorxiv.org/content/10.110…

Nature research paper: Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites go.nature.com/47TmCuf