1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators Masashi Nomura, Kevin C. Johnson and Luciano Garofano, which was published Nature Genetics! nature.com/articles/s4158…

3/ We first leveraged this large cohort to revisit the intra- and inter-tumor heterogeneity in GBM and characterized three multi-layered transcriptional ecosystems. Read more about this study in this great thread by @Masashi → x.com/M_Nomura/statu…

4/ And now for the results! Across the cohort the most consistent change at recurrence was reduced malignant cell fraction, with a reciprocal increase in glial and neuronal TME cells. This was observed in ~66% of patients, suggesting increased tumor integration into brain tissue.

11/ To sum-up, our multi-center study offers a high-resolution atlas of GBM recurrence dynamics, shaped by treatment response and TME context and underscores the tremendous heterogeneity of this devastating disease.

12/ Big thanks to the PIs that supervised the project Tirosh Lab, Mario Suva, Roel Verhaak, Antonio Iavarone and Anna Lasorella, all collaborators and institutions involved in the CARE consortium Weizmann Institute, MGH Pathology, Broad Institute, Yale School of Medicine and Miami University.

13/ Big thanks also to the institutions that provided tumor samples Duke University, MD Anderson Cancer Center, Tokyo University Hospital, Pitié-Salpêtrière Hospital, St. Michael's Hospital, Seoul National University and NORLUX and funders NIH, National Cancer Institute, Mark Foundation and Sontag Foundation.

Great to meet one of my greatest mentors, Dan Landau at the 15AGW conference. Thank you, Dan, for visiting Japan and giving your wonderful talk, as always! I hope you enjoy your rest of time in Japan!