Heard the justification for the ACS moving the starting age for colorectal cancer screening from 50 to 45 yesterday. Bottom line: the incidence of colorectal cancer in 45 year olds in 2015 is the same as it was for 50 year olds back in 1993.

AHEAD OF PRINT: Utility of Expedited #HereditaryCancerTesting in the Surgical Management of Patients with a New #BreastCancer Diagnosis. ow.ly/pPLj30lCWYX Kelly McMasters, MD, PhD Society of Surgical Oncology

Excited to share a new publication from our team here GeneDx looking at CDH1 penetrance. Lifetime risk for gastric cancer by age 80 is lower than previously reported: 42% for men and 33% for women. 20% of families report a history of breast cancer but no gastric cancer.

2 important changes to the 2019 USPSTF updated BRCA1/2 screening recommendation:1) Inclusion of women with previous breast cancer or ovarian cancer who are considered cancer free 2. Explicit inclusion of ancestry as a risk factor ja.ma/2P4HZ6z

While these new estimates are helpful, we must remind patients that we still are not able to give individualized estimates of cancer risk for #CDH1. This is why research matters NIH. NoStomachForCancer Go Without Your Gut

Role of EGD for patients with germline CDH1 pathogenic variants? One patient progressed beyond pT1a but declined PTG despite concerns identified via endoscopy. #insight2022 Jeremy L. Davis MD, FACS Grace-Ann Fasaye, ScM, CGC

Much needed initial CTNNA1 penetrance estimates! As illustrated by CDH1, these are subject to ascertainment bias and likely lower and presented here. but how much lower? What is needed in the US to conclude that CTNNA1 is disease causing? #insight2022

What an honor to hear Parry Guilford, MD, PhD speak at #insight2022. Is chemoprevention on the horizon for individuals with CDH1 PVs? Very excited to hear what comes from his research in the coming years.

Wendy Frankel, MD gave a great talk on just why GI Pathologist can be your best friend in GI Genetics. Share clinical suspicion and known diagnoses with your GI Pathologists and it can aid in histological classification! #insight2022

Lynch syndrome is associated with several cancer types, including #ovarian cancer in women. What about breast cancer? We summarize an important paper from Genetics in Medicine ht.ly/prtj30i9tyj #Grandrounds #genes #genetictesting #meded #FOAMed GeneDx Columbia University #hcsm

Proud to announce our first twitter journal club in 2 weeks - Feb 20 at 8 PM ET / 5 PT. Maegan Roberts will be joining us to discuss her paper on the association of breast cancer and Lynch syndrome due to MSH6 and PMS2 mutations. Details on how to join in to come soon.

Excited to be participating in a journal club hosted by CGA-IGC discussing my recent publication in Genetics in Medicine on Tuesday, February 20th from 8-9pm EST. Please join us, I anticipate a great discussion. #MSH6 #PMS2 #Lynchsyndrome #breastcancer x.com/GeneDx/status/…

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Happy #ValentinesDay, geneticists!

Two opportunities to ask questions about our recent publication in gim 🇺🇦 (parody AF) regarding #Lynchsyndrome and #breastcancer. Special thanks to GeneDx for hosting a webinar and CGA-IGC for hosting a journal club here on Twitter #CGAjc. x.com/GeneDx/status/…

Today is the day! I am really looking forward to a great discussion with colleagues. Please join us tonight at 8pm EST (5pm PST). CGA-IGC Maegan Roberts #CGAjc. x.com/CGAIGC/status/…

Hi everyone! I'm here and looking forward to a great discussion. #CGAjc