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An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo pnas.org/content/116/24… PNASNews MGH Center for Systems Biology Mass General Imaging Institute for Innovation in Imaging @MGH_RI MGHNeuroRadFellows

A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales thno.org/v09p7525.htm #Theranostics Theranostics Institute for Innovation in Imaging MGH Center for Systems Biology Mass General Imaging @MGH_RI MGHNeuroRadFellows

Happy Holidays!

Novel Coronavirus: What Neuroradiologists as Citizens of the World Need to Know ajnr.org/content/early/… alberto nuñez MGH Center for Systems Biology Institute for Innovation in Imaging

A more powerful molecular MRI agent (4-10X higher than conventional MRI agents) to report on myeloperoxidase activity, which reflects oxidative stress and damaging inflammation. doi.org/10.1021/acs.jm…. Mass General Imaging MGH Center for Systems Biology MGHNeuroRadFellows Harvard Medical School @MGH_RI JMedChem

Does gadolinium deposition in the brain have clinical consequence? Lessons from animal studies. doi.org/10.1148/radiol… Radiology Mass General Imaging MGH Center for Systems Biology Institute for Innovation in Imaging @MGH_RI MGHNeuroRadFellows

In this editorial, Dr. Chen discusses results from the article by Akai et al. on mouse model investigation of gadolinium brain deposition and behavioral testing, as well as the safety and medicolegal impact of these results. bit.ly/3gPgGss MGH JWChen Lab @HarvardMed

Great symposium on translational imaging of inflammation coming up at the end of October. Hope to see you there! i3.mgh.harvard.edu/inflammation/ i3 Imaging Symposium MGH Center for Systems Biology Mass General Imaging MGH Martinos Center @MGH_RI MGHNeuroRadFellows James Brink, MD Matthias Nahrendorf Fil Swirski & Scientists MGH Radiology Chiefs UCSF Imaging

D-mannose, a commonly available dietary supplement and a simple sugar, can improve neuroinflammation by suppressing oxidative stress and blocking phagocytosis. doi.org/10.1073/pnas.2… PNASNews MGH Center for Systems Biology James Brink, MD MGH Radiology Chiefs @MGH_RI MGHNeuroRadFellows Institute for Innovation in Imaging Caravan Lab

Myeloperoxidase, a highly oxidizing enzyme, exerts anti-tumor activity in glioma after radiotherapy. This could help optimize host immune response and therapy for this devastating disease. sciencedirect.com/science/articl… MGH Center for Systems Biology James Brink, MD MGH Radiology Chiefs @MGH_RI MGHNeuroRadFellows Institute for Innovation in Imaging

Grand opening of the i3, with Dr. Brink, Chief of MGB Enterprise Radiology, describing the founding of the i3. Mass General Imaging @MGH_RI James Brink, MD

Grand opening of the i3, with Dr. Chen, Co-Director of the i3, giving an overview of the i3. Mass General Imaging @MGH_RI James Brink, MD MGH JWChen Lab

Grand opening of the i3, with Dr. Arnold, Executive Director of the CTRU, describing the collaboration between i3 and IBC to form the CTRU to provide translational clinical research services. @MGH_RI

Grand opening of the i3, with Dr. Caravan, Co-Director of the i3, giving examples of translational work and first-in-man studies. James Brink, MD @MGH_RI Mass General Imaging 🇺🇦Peter Caravan🇺🇦

Grand opening of the i3, with Dr. Dubach, Associate Director of the i3, discussing i3 services, facilities, and equipment. James Brink, MD @MGH_RI Mass General Imaging

Grand opening of the i3, ribbon cutting, with Drs. Brink (center), Rosen (left), Weissleder (right), Caravan (far left), and Chen (far right). James Brink, MD @MGH_RI Mass General Imaging Weissleder MGH Center for Systems Biology MGH JWChen Lab

Grand opening of the i3, reception, with everyone having a great time. @MGH_RI Mass General Imaging