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Today #CancerGrandChallenges team eDyNAmiC and their international collaborators published 3️⃣ papers in nature 📣 They show the prevalence of ecDNA in cancer, identify fundamental mechanisms and an actionable target now being tested in the clinic. More: bit.ly/4dUMU00

Congrats Cancer Grand Challenges team eDyNAmiC- 3 papers in nature and ecDNA on the cover🥳 But how did we get here?! Read more about how Mischel Lab Howard Chang and @MariamJHanjani came to work on ecDNA, the incredible team and their findings cancergrandchallenges.org/news/team-edyn…

Three papers and the cover of nature on ecDNA !!! 🔥🔥 What an amazing achievement by our Cancer Grand Challenges team eDyNAmiC led by Mischel Lab Howard Chang Charles Swanton @MariamJHanjani Chris Bailey King L Hung and many more !!! 👏🏻👏🏻👏🏻👏🏻🍾🍾🍾🍾 Much more to come soon.

4 papers nature today on extrachromosomal (ec)DNA and cancer —Present in 17% of cancers —Suppresses the immune response —Prognostic significance (figure) nature.com/articles/s4158… Charles Swanton and colleagues

Also, let's take a moment to appreciate the beauty of this cover, which shows extrachromosomal DNA (ecDNA) next to chromosomes. ecDNAs are linked to therapy resistance and poorer outcomes for patients. Credit: E. MacKenzie and J. Claus (Phospho) nature.com/nature/volumes…

Three #ecDNA publications in Nature today - congrats Mischel Lab and Howard Chang! One key paper highlights the importance of CHK1, a critical therapeutic vulnerability in ecDNA cancer, and the biological target of our lead program, BBI-355. More here: nature.com/articles/s4158…

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. Today we report in nature that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ nature.com/articles/s4158…

Ecstatic to see our latest effort published in nature! It's been a privilege co-leading this project with King L Hung, Ivy Tsz-Lo Wong, and EJ. We combined single-cell genomics, imaging, and evolutionary modeling to find that cooperative ecDNA species are co-inherited in mitosis.

SCI members Howard Chang & Mischel Lab found that 17.1% of tumors contained #ecDNA. ecDNA was > after targeted therapy or cytotoxic treatments. The presence of ecDNA was associated with metastasis & poorer overall survival. go.nature.com/3YVmWFx

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in nature nature.com/articles/s4158…

Nature 2024年11月7日号 「外からの影響：染色体外DNAのがんへの影響を探る」 #ecDNA #がん治療 #nature go.nature.com/3NVVZuP

Hot off the press!! 🔥 Check out our work on the origins and impact of ecDNA. This was a team effort involving multiple collaborators as one of a three part series on ecDNA in nature

On dirait une forêt, mais il s'agit en réalité... d'un seul arbre de 47 000 troncs qui couvre une superficie de 42,6 hectares dans l'Utah 🇺🇸. Son âge est estimé entre 16 000 et 80 000 ans, faisant de lui le plus vieil organisme vivants sur Terre Source : nature.com/articles/d4158…

Il y a quelques années, les voix des élèves de l'école de musique afghane résonnaient à Kaboul. Aujourd'hui, le silence règne. Les talibans ont fermé l'école, interdit la musique et interdit aux femmes et aux filles de chanter Habib Khan

Investigating structural variants? I just released a tutorial video showing how I do this quickly and intuitively using my tools Ribbon and SplitThreader: youtu.be/TP-H9epbsTM

VERY excited to share SeqTagger with the world! If you want to learn more about our super-fast and accurate demultiplexing tool for direct RNA-sequencing (DRS), check out the thread below. bit.ly/3ClVYxG (1/15) 🧵

Amazing!

How to make this circos plot in 1 minute using Circa 2.0 youtu.be/e_zjPY2vpaM

Today we report Evo, a generalist foundation model for biology, on the cover of Science Magazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

I think the picture got lost the first time, let 's try that again. Here are all 25 talks together!