Pyrophosphorylation is extensive in human proteins. (phosphorylation of pSer to ppSer)

nature.com/articles/s4158…

New review of evidence for protein diffusion in extracellular matrix, involving sliding, chain switching and rolling interactions of proteins with heparan sulfate led by Dave Fernig (migrating) Biochemistry, Cell and Systems Biology Inst of Systems, Molecular & Integrative Biology
portlandpress.com/essaysbiochem/…

Important from Urszula McClurg 🇺🇦 Inst of Systems, Molecular & Integrative Biology. Agree totally: 'By improving accessibility, we not only enhance the conference experience for all, but also inspire a new generation of scientists who can envision success in an inclusive profession'.
doi.org/10.1038/s41556…

Sulantrix Ltd are delighted to be sponsoring the 2024 EMBO workshop on pseudoenzymes in Spain, June 10th-13th 2024 meetings.embo.org/event/24-pseud… organised by James Murphy zeqiraj Hayley Sharpe EMBO

Check out work from our department as well as Biochemistry, Cell and Systems Biology Inst of Systems, Molecular & Integrative Biology

ZechLab Eleanor Hargreaves

bxv_biochem

🎉 Abstract submissions are open for our new annual #BiochemSocFest ! Let's celebrate the scientific disciplines and activities that define the Biochemical Society's work. Submit your abstract to one of our 8 research areas before 9 May: ow.ly/BKyA50QrjJB

A big Liverpool welcome to Dr Kirsty McMillan Biochemistry, Cell and Systems Biology to give today's Inst of Systems, Molecular & Integrative Biology seminar. We can't wait for Kirsty to start as a Tenure Track Fellow at @LivUni later this year!

The more we learn about patient-specific PKA signaling in disease, the more interesting it gets. Great UK/US collaboration published today Science Advances
Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs science.org/doi/10.1126/sc…

Latest from our conformational ensemble prediction pipeline with modified AlphaFold2:

This is NOT a trajectory from MD!

It took two hours to predict this conformational ensemble using one GPU.

The experimentally-resolved energy barrier for this transition is > 15 kcal/mol

Fantastic to see this work from Biochemistry, Cell and Systems Biology Inst of Systems, Molecular & Integrative Biology on the front cover of J Cell Science. Congratulations to everyone!

Great opportunity to present your latest research into Mechanisms and Consequences of Redox Signaling at grc.org/thiol-based-re… -many talks to be selected from abstracts but program already very exciting. grc.org/thiol-based-re… too if you are an early career researcher.

George Carter is a 3rd year Microbiology student in @LivUniLifeSci - read about his experiences on a lab placement UC San Francisco in our latest blog: bit.ly/3tJYpqd

#research

Ok in honour of #jungleimafraid , the absolute heroes at BBC Radio 6 Music have released my #Cloudbusting mix for this coming Friday’s show with the legend that is Lauren Laverne

First one goes out to all original junglists

Happy Saturday night BBC Sounds

bbc.co.uk/sounds/play/m0…

The EMBO practical course on NMR spectroscopy will be held in Grenoble this year. If you are interested, you can sign up here to be informed when the course is open for applications: coming-soon.embo.org/pc24-35

2023 Small Molecule Approvals! drug hunter

A lot of fascinating firsts in 2023 including:

-The first FDA-approved oral ER degrader
-The first FDA-approved reversible BTK inhibitor
-The first FDA-approved gamma-secretase inhibitor (not in Alzheimer’s!)
-A reversible…

Join us for Professor Ian Copple's (Copple lab) free inaugural lecture highlighting the mechanisms used by the cells of the body to respond to various types of stress

🗓️ Wednesday 31 January
🕞 15:30 - 16:30

Register: bit.ly/47s8Oo9

Very happy to share our work uncovering the mystery of how the giant E3 UBR4 carries out ubiquitination.
#ubiquitin
#E3ligase
nature.com/articles/s4159…

So happy for Prof. Saye Khoo from Inst of Systems, Molecular & Integrative Biology Faculty of Health and Life Sciences @livUni for his MBE!

Professor Saye Hock Khoo, who is Professor of Pharmacology and Therapeutics at the University of Liverpool, has been made an MBE For services to Infectious Diseases and Pharmacology

Risk of dying from cancer in some poorer districts of England over 70% higher than wealthy districts, a new study in The Lancet Oncology suggests

hubs.li/Q02cGh2Q0

Join us for our Christmas Lecture presented by STEM ambassador and keynote speaker Ayosokale on neurodiversity and mental health challenges

🗓️Thursday 14 December, 13:30 @ 502 Teaching Hub

Free to register: eventbrite.co.uk/e/christmas-le…