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Chemoselective and Diastereoselective Synthesis of C-Aryl Nucleoside Analogues by Nickel-Catalyzed #CrossCoupling of Furanosyl Acetates with Aryl Iodides (Li) Chao Li Lab onlinelibrary.wiley.com/doi/10.1002/an…

#TotalSynthesis of the Potent and Broad-Spectrum Antibiotics Amycolamicin and Kibdelomycin by Shaoqiang Yang, Chenglong Chen, Jie Chen, and Chao Li Chao Li Lab in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

So happy to finish this complex natural product!

I am very glad to discover some new TEMPO chemistry in natural product synthesis!

#LCSOSynthesisProblem of the week! Elija challenged us with the synthesis of Amycolamicin and Kibdelomycin from Chao Li Lab in J. Am. Chem. Soc. ! #Totalsynthesis Take a look: epfl.ch/labs/lcso/wp-c… For original paper: pubs.acs.org/doi/pdf/10.102…

Electroaffinity labeling: a powerful new tool for target identification and Chemical Biology. Appearing today in ChemRxiv, a collaboration with brilliant Merck scientists: bit.ly/3B5eSEv

An atroposelective synthesis of Darobactin, appearing today in ChemRxiv : bit.ly/3z9tJyC

🎁Do you recognize this PhD student in front of his hood in 1999? There he started out to become a true artist in Total Synthesis. Birthday present: autobio of S. Kent l-i-c.org/1129, the artist of Total Synthesis of #Peptides/#Proteins & #NativeChemicalLigation. Cheers!

Final version of this study was published today in J. Am. Chem. Soc. : bit.ly/3QGPDhP

Congratulations to chemist Prof. Phil Baran, who has been awarded the 2022 Danisco Foundation Science Excellence Award from IFF. Baran is recognized for advancing science and technology relevant to the future of food, nutrition, and health magazine.scripps.edu/awards-and-hon… Baran Lab

Please check out our total synthesis of (−)-Peyssonnoside A J. Am. Chem. Soc.. Big congratulations to Bo Robort and Chang! Catalysis-Enabled 13-Step Total Synthesis of (−)-Peyssonnoside A pubs.acs.org/doi/10.1021/ja…

Today we report in ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with Chris Parker and Luke Lairson the remarkable biological activity of this natural product family was revealed

Modern alchemy appearing today in Science Magazine : science.org/doi/10.1126/sc… Commentary (thank you Prof. Ye!): science.org/doi/10.1126/sc…

Hopefully, this recent work from our group will help some medicinal chemists. A general C(sp2)–I selective C(sp2)–C(sp3) cross-electrophile coupling. onlinelibrary.wiley.com/doi/10.1002/an…

Nickel-Catalyzed C-I-Selective C(sp2)-C(sp3) Cross-Electrophile Coupling of Bromo(iodo)arenes with Alkyl Bromides (Chao Li and co-workers) Chao Li Lab onlinelibrary.wiley.com/doi/10.1002/an…

Excited to share our latest paper on the total synthesis of Illicium sesquiterpenes. Not only access more targets but synthetically connect distinct molecular architectures of different subfamilies through late-stage skeletal reorganization triggered by Lewis acids or oxidants.

The final version of this study was published today in nature : nature.com/articles/s4158…

We're excited to have achieved a structure-activity relationship analysis of the complex natural antibiotics Kibdelomycin/Amycolamicin through total synthesis. We hope this work will contribute to the development of new antibiotic therapies. onlinelibrary.wiley.com/doi/10.1002/an…

Establishing the Comprehensive Structure-Activity Relationship of the Natural Antibiotic Kibdelomycin/Amycolamicin (Chao Li and co-workers) Chao Li Lab onlinelibrary.wiley.com/doi/10.1002/an…

Thrilled to share our progress on the synthesis of highly oxidized DMOA-derived meroterpenoids—now out in JACS:pubs.acs.org/doi/10.1021/ja…! The unexpected reaction we stumbled upon in the final step turned out to be especially fascinating.