My lab is hosting a happy hour together with Zenobi-Wong and Schwank labs. The theme is airports. What you see here is a homebrew, working metal detector with alarm that attendees pass through upon exiting the elevator. Welcome to ETH Zurich, where even the biologists are techies.

New preprint from the Gerald Schwank! We present a novel base editor variant (HNHx-ABE) with a shifted editing window and reduced size. Congratulations to Lukas Villiger and everyone involved in this elegant study!💪 biorxiv.org/content/10.110…

New preprint of Gerald Schwank on bioRxiv. Congrats Patrik Simmler and collaborators for this nice story!

Excited to see our study "Predicting prime editing efficiency and product purity by deep learning" published in Nature Biotechnology today! Gerald Schwank Krauthammer Lab nature.com/articles/s4158… 1/14

🎙️Excited to launch my new podcast #CRISPRli, a deep dive into the revolutionary world of #CRISPR. I'll be hosting interviews with top genome editing experts. Ideal for scientists, students or anyone curious about this cutting-edge tech. #GeneEditing open.spotify.com/show/1NDD79fy2…

🚨New preprint🚨Today, we're excited to share our latest study, "Predicting prime editing efficiency across diverse edit types and chromatin contexts with machine learning" via bioRxiv! Gerald Schwank Krauthammer Lab Bas van Steensel lab UZH Science biorxiv.org/content/10.110… 🧵

Impossible to do the field justice on a few pages but we (Jonathan Gootenberg Omar Abudayyeh @jsw Julia Joung Luke Koblan) tried our best to give an overview of current CRISPR technologies in Nature Reviews Molecular Cell Biology rdcu.be/dxDD9

Our paper exploring the effect of chromatin on prime editing and diverse pegRNA designs was published today! 👨‍💻🧬🎉 rdcu.be/dLu0f pridict.it UZH Science Nature Biotechnology Gerald Schwank Krauthammer Lab Bas van Steensel lab 🧵

Excited to share our latest study! Today in Nature Methods the Gerald Schwank and Krauthammer Lab report in Kim Fabiano Marquart et al. 'Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs' (1/6) nature.com/articles/s4159…

TnpB is much smaller than the well-known CRISPR-Cas "gene scissors". The tool for targeted modification of the genome has now been improved to such an extent that it could one day be used to treat a genetic defect that leads to a lifelong high cholesterol level.

If you're more of a visual learner, this explainer video is for you 🙌

Our paper describing an RNA-LNP prime editing strategy for treating phenylketonuria was published today in Nature Biomedical Engineering (1/7) nature.com/articles/s4155… Gerald Schwank UZH Science University of Zurich Kinderspital Zürich ETH Zurich