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Register for #ReThinkNeuroimmunology 🔗genelayinstitute.org/rtn/ Talks by Brain-Immune Communication Lab Schaefer Lab Anna Molofsky Brian S. Kim Caroline Sokol MDPhD Evan Macosko Feng Zhang @realFlorentGinhoux GonçaloCasteloBranco Hai Qi Chiu Lab The Colonna Lab Miriam Merad, MD, PhD Yosef Lab Oleg Butovsky Kuchroo Lab +more

Wow, wow, wow! Psychedelic control of neuroimmune interactions governing fear #psychedelics nature.com/articles/s4158…

Led by Vijay Kuchroo and Oleg Butovsky, our group just published a paper in Nature showing treatment of Alzheimer’s disease by TIM-3 mediated regulation of microglia: tinyurl.com/5572mfb9. Immunology plays a major role in AD over and above anti-amyloid therapy. Very exciting!

Researchers Gene Lay Institute of Immunology & Inflammation show that psychedelic compounds regulate neuroimmune interactions to control stress-induced fear. Study from Michael Wheeler’s (Michael Wheeler) lab, now published nature. Mass General Brigham Research Harvard Medical School

Congratulations Michael Wheeler et al. on this elegant study showing the underlying mechanisms of how psychedelics influence neuroimmune interactions with implications for fear behaviour. Delighted to be able to contribute to this work. nature.com/articles/s4158…

Our research on how the immune checkpoint TIM-3 regulates microglia & Alzheimer's disease highlighted in the Harvard University Gazette. news.harvard.edu/gazette/story/…

The lab family are also thrilled!🙌

So great that Brenda & Jason gave us daily recaps of their favorite talks at #AAI2025 Immunology Podcast. This episode features a talk by Ana Anderson Ana Anderson lab on how opioids drive immunosuppression in T cells in cancer. Hear about this & more👇

Kudos to Francisco and the Fran Quintana Lab on this beautiful work. Glioblastoma-instructed astrocytes suppress tumor-specific T cell immunity.

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense science.org/doi/10.1126/sc… Science Magazine Rocky Barilla Kuchroo Lab Xavier Lab

Out now in @Science! We and the Kuchroo Lab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity. science.org/doi/10.1126/sc…

(1/6) Exciting! Our latest paper in Cell Host & Microbe shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway. cell.com/cell-host-micr…

What a huge effort from grad student Rocky Barilla who was responsible for driving this project. Well done to Rocky & everyone involved.

NPR story on 1st AD pt. Rx w/nasal foralumab shorturl.at/ba16d Moderate AD- not eligible for lecanemab. Expanded access Rx. Tolerating it well. To begin controlled trial at BWH in mild AD. Lost my mom to AD who asked “Howie, can you help me?” I couldn’t then, but could now.

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity Cell Reports Nir Yosef Kuchroo Lab cell.com/cell-reports/f…

Happy to share that this study led by Wang Lab Allon Wagner & Johannes Fessler, in collaboration with Yosef Lab, is now published Cell Reports. We uncover that the glycolytic enzyme, PGAM, suppresses Th17 pathogenicity & autoimmunity cell.com/cell-reports/f…

And just like that - Brigham and Women's Hospital internal medicine residency ✅ laughter, tears, diet ginger ale, the greatest co-residents and my incredible family who supported me and raised my kids so I could be here today. It takes a village - and I have the best one ❤️ Brigham and Women's Medicine Residents

#RTN2025