If you diagnose a nodal T-cell lymphoma with these features: -Morphology is blastoid -No monotypic pattern of TRBC1 by flow cytometry analysis -No TCR gene rearrangement by PCR Add a marker of cell immaturity like TDT, CD34, CD117 etc, even if the clinical features are not

Congrats to our senior resident！👏👏👏

MS provides significant prognostic information in the maintenance setting and complements BM MRD in multiple myeloma. ow.ly/owAT50Ta2xT #clinicaltrialsandobservations #lympoidneoplasia #multiplemyeloma

Illustration of nodal CLL/SLL, with a spectrum of growth of proliferation centers (PCs), slowly evolving and replacing existing germinal centers (GCs)(represented in zones with high Ki67 expression in figures 1 & 2), until full nodal involvement (figures 3 & 4) #hemepath #lymsm

Congratulations to the authors 4 finally putting this decade-long ❓ to rest. Nature Medicine We can all sleep better (or worse 😬) tonight, knowing CH causes atherosclerosis & not the other way around. That’s some pretty “determinate” potential, I’d say 😉 TET2> DNMT3A & of

More on CLL/SLL, and the possible role of EBV infection in inducing disease acceleration➡️ Below is an example a lymph node, excised from a patient with CLL/SLL showing signs of clinical progression, to rule out Richter Transformation. Morphologic examination shows an

See you on this Thursday, 6-7PM EST. Scan the code and join us！

We have 3 residents starting the #MolPath rotation this week. Trying out creating graphics to illustrate molecular topics. Here’s my general example for DNA isolation. Each resident will get an opportunity to illustrate and teach a topic too.

Rare cases of FL/ DLBCL with BCL2 and IRF4 rearrangements exist, and should not be confused with large B-cell lymphoma with IRF4 rearrangement. FL/ DLBCL with BCL2 and IRF4 rearrangements typically show triple expression of CD10, BCL6 and MUM1 by IHC stains. FL/ DLBCL with

This is unicentric Castleman disease, hyaline vascular type. Occasionally B cells in follicle mantles coexpress CD5 in HVCD suggesting mantle cell lymphoma or SLL/CLL, but the patient’s young age & lack of cyclin D1 & LEF1 are against those possibilities. #Castleman #hemepath

Expanding on the theme of IRF4 rearrangement in B-cell lymphomas, beyond "large B-cell lymphoma with IRF4 rearrangement": EBV-associated DLBCL may in rare instances harbor IRF4 rearrangement. These cases appear to exhibit clinical, histologic, immunophenotypic and

Myeloid/lymphoid neoplasm with eosinophilia and PDGFRA-rearrangement. #hemepath #PathTwitter #pathology

Interfollicular classic Hodgkin lymphoma. CD30 and PAX5. #hemepath #PathTwitter #pathology

4 cases of ALK+ ALCL showing the variability in morphology. #hemepath #pathtwitter #pathology

This is TODAY! :)

Join a high impact academic medical center with a state-of-the-art molecular laboratory in a supportive setting (shameless plug 😁)

Cross-promotion alert😂😂😂 For folks interested in "warming up," Greg joined the "chromogen siblings" (Michael Arnold, MD, PhD, Sanam Loghavi, MD صنم لغوی 🔬🧬, and yours) for a fun The PathPod Podcast episode back in 2020. Have a listen here: podcasts.apple.com/us/podcast/ihc…

Visiting Montreal this weekend. On the lookout for murals.

Methven: Predicting the effect of non-coding mutations on single-cell DNA methylation using deep learning biorxiv.org/content/10.110…

A new fear unlocked: Leukemic non-nodal mantle cell lymphoma may involve the bone marrow in a very subtle sinusoidal way, as illustrated in figure 1 below with H&E and CCND1 stain highlighting a sinusoidal neoplastic lymphocytic infiltrate. In addition to this sneaky pattern of