Nice work here by Alessandro Sanzeni and with me & Nicolas Brunel. Alessandro’s impt results show how the balanced state—the fundamental model of cerebral cortical function—works in networks that are conductance-based, as real neurons are. Some surprises. Short 🧵: #neuroscience

Inspired by Kanaka Rajan tweet– Jonathan O'Rawe from our lab will present at #cosyne22/#cosyne2022. Stop by the 2nd poster sess., Fri Mar 18th, to discuss the results with him—on recurrent cortical suppression explained by a balanced-state cortical model. thx to Alessandro Sanzeni/1

New work investigating a surprising phenomenon we discovered in the visual cortex of mice and monkeys: optogenetic stimuli strongly modulate single neuron visual responses but weakly affect the overall activity of the network! Thread -> biorxiv.org/content/10.110…

Try to imagine where neuroscience would be without Patricia Goldman-Rakic. Go ahead...I'll wait.

Excitation creates a distributed pattern of cortical suppression due to varied recurrent input biorxiv.org/cgi/content/sh… #biorxiv_neursci

New preprint! “Activity in primate visual cortex is minimally driven by spontaneous movements”, biorxiv.org/cgi/content/sh…, by amazing team led by @BharathTalluri & Incheol Kang, with Adam Lazere, Nick Kaliss, @mightyrosequinn, & wonderful collaborators @jcbyts & Dan Butts. 1/8

Single cell optogenetics reveals attenuation-by-suppression in visual cortical neurons biorxiv.org/cgi/content/sh… #biorxiv_neursci

Sharing new preprint from our lab: bioRxiv Neuroscience. Led by Paul LaFosse, we show neurons in the awake🧠can filter out inputs: attenuation-by-suppression. Also: real neurons’ activation function share features w/ #ai systems (eg ChatGPT). #neuroscience Comments welcome! 1/15

We are so happy that this is now out Nature Neuroscience: nature.com/articles/s4159…

🧠🚨: Our latest paper is out today in Neuron! Led by Jonathan O'Rawe, we show salt-and-pepper excitation& suppression in mouse V1 arises from purely exc opto input. That means the excit-excit recurrent connections in cortex change how neurons respond to input. 1/3

New work with Agostina Palmigiano, Tuan Nguyen, Ken Miller, and Nicolas Brunel at Neuron : Unveiling the Mechanisms Behind Reshuffling Visual Responses via Optogenetic Stimulation in Mice and Monkeys 🐭🐒 (thread follows) cell.com/neuron/fulltex…

just got the first (expected) message advising me not to be so open abt my mental health struggles—especially addiction—pre-tenure. as if I’m the only academic who’s an addict. if academia doesn’t want an honest version of me, I’ll go elsewhere. I have a lot to offer.

Tough times in the world right now, but will share this: If you're attending SFN in DC this wknd, we have 2 posters on Sat I'm excited about. Paul LaFosse is presenting work on activation functions in cortical neurons,& Ciana Deveau on cortical recurrent nets 'doing sequences.'1/2

🚨Our latest out Nature Communications! 🚨 Why are drugs like Ritalin therapeutic when taken orally, but highly addictive when taken intravenously? We used simultaneous PET-fMRI with drug challenges to see how the rate of dopamine increases affects drug reward! rdcu.be/dqzOu

On Ciana and Zhishang's work on sequence processing in the cortex, here is a teaser of a graphical abstract for the poster, which is on Saturday at #SfN23. We find the visual cortical network in L2/3 selectively _filters_ sequences of inputs to populations of neurons.

If you'll be at Cosyne 2024 this week, please come by our posters: We have 3 presentations, by Paul LaFosse, Remy Yovanno&Bradley Akitake, and Ciana Deveau. All about what the recurrent network of sensory ctx does. Looking forward to seeing others' science at the meeting too!

Active filtering of sequences of neural activity by recurrent circuits of sensory cortex biorxiv.org/cgi/content/sh… #biorxiv_neursci

This is a new preprint we are excited about. Ciana Deveau will be talking about this work w/ Zhishang Zhou at Cosyne - please stop by. We'll post a tweet thread next week after Cosyne. #Cosyne2024 #cosyne24 #neuroscience #neuroai

When it comes to problems with academic publishing we are in fact the baddies. So many scholars really think pre-pub peer review works as quality control & published stuff is trustworthy. There is no easy fix to the quality problem, but ending publication as target is a beginning

Our latest now out PNASNews! Huge thanks to the team, and NIAAA News for support! pnas.org/doi/10.1073/pn…