Our study to test the efficacy of #AAV-GRN in rescuing motor deficits and #ALS #FTD pathology in #Tmem106b #Grn double KO mice just got published! Great collaboration with #Alector and #Postdoc Tuancheng Feng has done an amazing job! cell.com/iscience/fullt…

cell.com/cell/fulltext/…

Beaten to tweeting our paper by ShorterLab! Check out the RNAs that bind C9orf72 polyPR -we hope a useful resource for the field LifeScienceAlliance life-science-alliance.org/content/6/9/e2…

Here it is!! 🤩 Excited to announce that my first first-author paper from my PhD is now available as a preprint! Many thanks to my lab Switch Lab and our collaborators for the effort!

'The major #TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the #ageing human hippocampus' Jun Yup Lee ... Anthony S Don Charles Perkins Centre University of Sydney #lipidomics #proteomics bit.ly/3PJ4w61

My first first-author publication about #TMEM106B in the #hippocampus of ageing cognitively normal individuals has just been published Molecular Neurodegeneration …arneurodegeneration.biomedcentral.com/articles/10.11… #proteomics #lipidomics #neurodegeneration

Preprint: Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD We are excited to share our latest study on how PINK1/Parkin mitophagy initiation and progression is regulated. Out now on bioRxiv! 1/ biorxiv.org/content/10.110…

This #FTDAwarenessWeek, we're proud to be advocating for FTD research. RosaRademakersLab and her team are working hard to advance research on FTD 👇 To learn more about their work, visit 🔗rademakerslab.sites.vib.be/en #endFTD #WeCareAboutFTD 🩵

Very excited for my first time at #SfN23! 🧠 Find me at my poster tonight at the TPDA poster session (KK9) - or come check out my talk (NANO53.02) on Tuesday morning. Special thanks to SfN-Gatsby Charitable Foundation for the support!

Study identifies a fluid biomarker of TDP-43 dysfunction, a central pathological feature of the #ALS-FTD disease spectrum, and demonstrates that such loss of TDP-43 splicing repression occurs presymptomatically Johns Hopkins Pathology, Hopkins Neuroscience Katherine Irwin nature.com/articles/s4159…

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD | Science Translational Medicine science.org/doi/10.1126/sc…

We are proud to share our latest Genetic Information Guide, on the GRN variants associated with FTD. Focused on concepts of most interest to, and written to be accessible for, those impacted. endthelegacy.org/grn-guide

Very happy to share our article just published in Brain. Well done Dr. Saira Mirza and Maurice Pasternak. GENFI Sunnybrook Health Sciences Centre Department of Medicine University of Toronto UToronto Neurology : Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study academic.oup.com/brain/article/…

I'm happy to share that our paper describing our novel TMEM106B overexpression mouse model is now out in Molecular Neurodegeneration 🧠 It’s been a project with highs and lows, and seeing it published is incredibly rewarding. Thanks to everyone who was part of the journey 🙌.

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures cell.com/neuron/fulltex…

Methylome analysis of #FTLD patients with #TDP43 pathology identifies #epigenetic signatures specific to pathological subtypes Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman...Rosa Rademakers VIB Center for Molecular Neurology Mayo Clinic Neuro …arneurodegeneration.biomedcentral.com/articles/10.11…

The Progranulin Information Navigator provides: 📍 Clinical FTD trial directory 🧬 Free genetic counseling + testing for eligible participants 📚 Resources for families + providers 🔗 progranulinnavigator.org #FTDAwareness #FTDResearch #CureFTD #EndFTD #progranulin

'Molecular hallmarks of excitatory and inhibitory neuronal resilience to #AlzheimersDisease' Isabel Castanho, Pourya Naderi Yeganeh...Rudolph E. Tanzi Dr. Rudy Tanzi & Winston Hide Harvard Medical School BIDMC #CognitiveResilience #transcriptomics #genetics …arneurodegeneration.biomedcentral.com/articles/10.11…

Almost there! 🎓 Excited (and a bit surreal) to be defending my PhD soon! Welcome to join the defense 👇