🚨Thrilled to share our new pre-print about a gentle palette of plasma membrane dyes! 💥Alleviated Phototoxicity and Enhanced Photostability 🌟Versatile Compatibility 🔬Suitable for Long-Term Super-resolution imaging #phototoxicity #SuperResolution #Microscopy #CellMigration

😍 PKmem 555 in action! Thanks for sharing!

🔬Gentle Rhodamines generally offer alleviated phototoxicity enabling long time-lapse imaging of different organelles pubs.acs.org/doi/10.1021/ac… Awesome collaboration with Tianyan Liu, Julian Kompa, Kai Johnsson group and Spirochrome I've learned a lot from two great collaborators🥰

I'm flattered everytime I see a multi-color movie with our gentle dyes together with mStayGold!

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Our collaboration with FluoSphera 2nd episode: 2 types of cancer spheroids (HER2 positive and HER2 negative) were color coded with our PKmem probes and co-cultured in microcavity plates. Live cell imaging beautifully captures the progressive binding of trastuzumab-FITC (anti

Looking for a fluorescent biosensor and don’t know where to start? Want a comprehensive overview of the field? Check out our new review in Chemical Reviews online now as an ASAP article! From co-first authors Dr. Anneliese 💖💜💙 @AyseZSahan Yanghao Zhong doi.org/10.1021/acs.ch…

(1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB biorxiv.org/content/10.110…

Today, I would like to honor the memory of Roger Y. Tsien, born on February 1, 1952. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! nature.com/articles/nmeth… #FluorescenceFriday

Check out our new paper in Nature Biotechnology sharing our latest kinase activity reporters! Led by former postdoc Michelle Frei, these reporters are based on HaloTag rather than an FP, for far-red imaging and superresolution! nature.com/articles/s4158…

A suite of bridged rhodamine dyes for fluorescence microscopy, named BriDyes, offers excellent brightness, photostability, solubility, cell permeability, and resistance to photoblueing. nature.com/articles/s4159…

Here come our new palette of fluorescent dyes. The BD dyes endeaves to balance glowy brightness, robust photostability, and biocompatibility. Let's boost 4D dynamic super-resolution imaging!!! nature.com/articles/s4159… Spirochrome

Congrats🎉🎉🎉

🚨 PUBLISHED in PNAS tiny.cc/3qhp001 Introducing PK Mem: Gentle ✨, photostable ☀️membrane dyes for long-term live super-resolution imaging! Great collaboration with Yitong Li and Alexandre Dumoulin @axonsalex.bsky.social 🌟 Thank Peng Xi Lab & Hongyun Tang Lab for support!

PK Mem dyes were designed as a gentle alternative to time-lapse fluorescence imaging of cellular plasma membranes. The dyes are less phototoxic and more photostable than existing plasma membrane dyes. In PNAS: ow.ly/UClT50WuOxj

Very fancy ratiometric voltage imaging with dual-polarity voltage sensors Positive-going hybrid indicators for voltage imaging in excitable cells and tissues | Science Advances science.org/doi/full/10.11…