Tuning Hsp104 specificity to selectively detoxify alpha-synuclein biorxiv.org/content/10.110… via ShorterLab Korrie Mack Shorter Lab Members Guy Caldwelll Jackrel Lab Members Jiabei Lin Eddie Ryan Cupo

Hey everyone check out our paper that is finally out. Great work from everyone involved. Alex Rizo eric.tse Jiabei Lin Aaron L. Lucius ShorterLab Shorter Lab Members @SouthworthLab NatureStructMolBiol nature.com/articles/s4159…

Wonderful new animation by Janet Iwasa of the ClpAP nanomachine degrading polypeptide! @SouthworthLab Aaron L. Lucius Jiabei Lin Alex Rizo Dr. Kyle Lopez: youtube.com/watch?v=Vrmhhh…

Dedicated to Professor S. Walter Englander on the occasion of his 90th birthday :)

Rapid development of an inactivated vaccine candidate for SARS-CoV-2 science.sciencemag.org/content/early/…

The full tweet thread from out preprint can be found here: x.com/Ryan_Cupo/stat…

Congratulations to Justin on successfully defending his MS thesis today! He is the first graduate student to do so from my lab! He has worked hard to reach this day. Justin Marsee

R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation: nature.com/articles/s4146…

Allow International Students to Finish Their Degrees petitions.whitehouse.gov/petition/allow…

Anyone else with young school aged kids want to discuss what their plans are for fall, particularly if your children’s school is fully online? Feel free to DM. Floated ‘pod’ idea with other parents but got complicated fast.

Very cool paper from James Berger Lab: The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader biorxiv.org/content/10.110…

Please retweet: reminder to register for the The 26th Annual Midwest Stress Response and Molecular Chaperone (Virtual) Meeting, to be held Saturday, January 16, 2021, 9:00am-2:00pm CDT by Zoom webinar. Please see: groups.molbiosci.northwestern.edu/morimoto/MWSM/ #proteostasis #hsp70 #hsp90

Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells sciencedirect.com/science/articl… "Our proof-of-concept benchmark revealed...the ultrastructure of protein inclusions that recruit fluorescently-labeled chaperone Hsp104." Structure

Dr. Katalin Kariko, 66, is known to her colleagues as Kati. She's now also known as one of the heroes of coronavirus vaccine development. Alongside her collaborator, Dr. Drew Weissman, she laid the groundwork for the Pfizer-BioNTech and Moderna vaccines. nyti.ms/2OxWLDc

Comparative analysis of the coordinated motion of Hsp70s from different organelles observed by single-molecule three-color FRET pnas.org/content/118/33…

Daxx represents a new type of protein-folding enabler, excited that this work with Xiaolu Yang, Marmorstein Lab, Jiabei Lin et al. is out in nature! nature.com/articles/s4158…

Congratulations to our Dept. Chair, Kristen W. Lynch, PhD (@KristenWLynch1), recipient of the 2021 Michael P. Nusbaum Graduate Student Mentoring Award! This award is well-earned.

An excellent defense lecture by Ryan Cupo!!! Penn PGG Penn BGS

The FDA should allow Moderna and Pfizer to update their #COVID vaccine to match the mRNA to Beta, Delta, and/or #Omnicron. It would be much more effective than boosting with the original Spike and would be comparable to the way we treat seasonal influenza virus vaccines each year

AAA+ proteins: one motor, multiple ways to work, it was great to write this review for Biochemical Society Trans Portland Press with Jiabei Lin & Aaron L. Lucius: portlandpress.com/biochemsoctran…