Mahlon DeLong (1938-2024) was the GOAT in his long-running career as a combined neurologist and neuroscientist. He took great care of the world's GOAT (Ali), however this is one title (GOAT neurologist-neuroscientist) that belongs to him, and him alone. It is with a heavy heart

Tourette to 2024 in 30 mins.

A master at work at #IAPRD2024 Christos Ganos

#IAPRD2024 #welcomeceremony #Fado #Lisbon #Portugal

IAPRD

Have you seen or maybe missed chorea associated with CADASIL? The syndrome is associated w/ migraine, subcortical ischemic events (stroke), cognitive impairment (dementia), disability, and psychiatric disorders. Check out the dancing disorder associated w/ the Notch3 gene

Rest in peace to the term, extrapyramidal system. Abhishek Lenka and Joseph Jankovic put the final nail in the coffin in their new piece in Neurology Journal Neurology Clinical Practice.
Key Points:
- Johann Prus coined the term extrapyramidal in 1898.
- He experimented on dogs and

All of us have used the term “extrapyramidal system”/extrapyramidal symptom” (EPS) in our careers. However, is it an accurate/useful term?

In the following article in Neurology: Clinical Practice, Joseph Jankovic and I suggest it may be time to lay this term to rest!

neurology.org/doi/10.1212/CP…

Abhishek Lenka Charenya Anandan Congratulations to our fabulous DBS team. PDCMDC Michael Okun MDS

It's not often you find knives, chopping boards, and fruits in the clinic, but today was different! A patient with essential tremor (post-VIM DBS) brought her tools. Now, she is happy with the tremor-free slicing after DBS.

An 🍎 a day does not keep the doctor away! Charenya Anandan

Are dystonias immunological disorders? New study by Scorr, Jinnah and colleagues Parkinsonism & Related Disorders w/ editorial Joseph Jankovic explores this possibility. Data was from cervical dystonia.
Key Points:
- The study looked at cervical dystonia.
- Serum immunoassays comparing cervival

Attended the first editorial board meeting for Dystonia, official journal Dystonia Medical Research Foundation.

#dystonia #journal
@pdcmdc Alfonso Fasano Michael Okun Mark Hallett Alberto J Espay

Today JAMA published the results of a study of skin bx showing the presence of cutaneous phosphorylated α-synuclein in >90% of patients with synucleinopathies.
pubmed.ncbi.nlm.nih.gov/38506839/
I noted that the skin may be a window to the brain in a WSJ interview:
wsj.com/health/parkins…

Michael Okun Nature Medicine This is a very important study which hopefully will be confirmed by the PADOVA trial. I am honored to play a role in the initial trial and in the tremor-dominant vs PIGD subtyping used in this analysis.PDCMDC Michael Okun MDS

Joslyn Chaiprasert-Paguio Elsevier ElsevierNeuroscience I am honored to be part of Elsevier author family. Michael Okun PDCMDC MDS

Nature Medicine Azad Bonni This is a very important paper drawing attention to potential benefits of monoclonal antibodies targeting synuclein as disease modifying therapy. I am glad I was able to contribute to the initial trial and to the development of tremor-dominant vs PIGD subtyping of PD. PDCMDC

AAN movement disorders section meeting. Great folks and what a great discipline started by @stanfahn, Mark Hallett david marsden Joseph Jankovic
Abhimanyu Mahajan Indu Subramanian Brandon Barton, MD

Shilpa Chitnis, M.D., Ph.D., FAAN. Mark Hallett david marsden Abhimanyu Mahajan Indu Subramanian Brandon Barton, MD I am delighted that the AAN movement disorder section is thriving. PDCMDC MDS Michael Okun

Enjoying the AAN annual meeting and reconnecting with my friends.Michael Okun MDS American Academy of Neurology PDCMDC

Here is an excellent review by Raja Mehanna and Joseph Jankovic on systemic symptoms of Huntington’s disease HD) that was recently published in Movement Disorders Clinical Practice .

HD is much beyond chorea and neuropsychiatric symptoms!

…mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Chorea special series, episode 1: Prof. Joseph Jankovic shares his expert insight on differentiating chorea phenomenology from other movement disorders. With guest host Dr. Ruth Walker. loom.ly/hKAC6L4

Can you recognize a re-emergent tremor in the setting of Parkinson's disease? 'One type of postural tremor are rest tremors that re-emerge after a variable delay while maintaining posture.' Described by Jankovic, physiology by muthuraman and example video by Boby.
Nice review