Our next webinar on FBDD and compound optimization is available for registration! Join Jan Wollenhaupt and to discuss efficient fragment screening and the subsequent improvement of discovered hits performed at Helmholtz-Zentrum Berlin. biosolveit.de/webinar/crysta… #medchem #compchem #CADD #drugdesign

Eager to learn more about crystallographic fragment screening, meet experts of the field, get to know how iNEXT-Discovery sites do it and get hands-on training on sample and data handling? Apply for our iNEXT DISCOVERY course Helmholtz-Zentrum Berlin, 1st-3rd March 2023! helmholtz-berlin.de/events/inext-d…

Join us for the last CFBD Seminar Series in 2023! Hear A/Prof Anders Bach from the Bach Group at University of Copenhagen Research. Register here: bit.ly/3UjzLnF EMCR_MIPS Monash Institute of Pharmaceutical Sciences GRIDD Kassiou Group Joel Mackay Prof Sally-Ann Poulsen🌻 ARC CCeMMP

Here's the slide that took me 6 months to make. The six classes of molecular interactions for drug design. Clearly H-bonds are the first thing to master as a drug designer followed by pi-pi and sigma-sigma interactions.

We wish everyone a happy new year, and hope that all your crystals will diffract! If you are interested in crystallographic fragment screening, don't forget to apply for our course, deadline this Friday! helmholtz-berlin.de/events/inext-d…

Open position in the MX group - Computational scientist for new methods - Application deadline February 28 - Come join us!

Out now in Chemistry: a new paper from our collaboration with the Schwalbe group Schwalbe Lab, with contributions from Frank Lennartz, Jan Wollenhaupt and Manfred S. Weiss. You can read about it here: doi.org/10.1002/chem.2… Helmholtz-Zentrum Berlin BESSY@HZB

finished a great first day of our iNEXT-Discovery course with poster session + dinner, looking forward to day two BESSY@HZB

Today, the first day of the second quarter, Practical Fragments launches a very modern effort to monetize chemical space practicalfragments.blogspot.com/2023/04/profit…

If you are attending @IUCR2023 and are interested in hearing all about crystallographic fragment screening, including a talk from our groups' Tatjana, then hurry up and register for the satellite workshop here: ansto.gov.au/whats-on/recen… Helmholtz-Zentrum Berlin BESSY@HZB

This evening, Laila Benz from our group will present a poster about her project to screen for drug candidates against SARS-CoV-2 MPro at the European Congress of Virology in Gdansk. Come and visit her at poster 022! Helmholtz-Zentrum Berlin BESSY@HZB

First PhD from the MX group! Congratulations to Dr. Tatjana Barthel, who just defended her thesis and passed with flying colours!! BESSY@HZB Helmholtz-Zentrum Berlin @adler

Suche nach neuen Antibiotika: Der Wirkstoff aus dem Matsch tagesschau.de/wissen/forschu… #Antibiotika #Bakterien #Resistenz

Out now in Structural Biology: a paper with data from BL14.1 and contributions from Manfred S. Weiss and Jan Wollenhaupt. If you want to read more about fragment-based approaches targeting mycobacterial thioredoxin reductases, check the paper out here: journals.iucr.org/d/issues/2023/… Helmholtz-Zentrum Berlin

Congratulations the German Crystallographic association and AK Junge Kristallographen/Young Crystallographers for confirmation that IUCr 2029 will be held in Berlin!

Yes, we made it 🙌 🎊 🎊

Fragment screening on M. smegmatis thioredoxin reductase showed 68 binding events, with 42 fragments found at 11 different binding sites @WWU_Muenster IUCr #CrystallographicFragmentScreening #MycobacteriumTuberculosis #MycobacteriumSmegmatis doi.org/10.1107/S20597…

Are you interested in a post-doc position that allows you to do exciting science using x-ray crystallography? Then come and join us as part of the joint MX collaboration! More information and how to apply here (website in german): haushalt-und-personal.hu-berlin.de/de/personal/st… Helmholtz-Zentrum Berlin BESSY@HZB

A new paper is online: Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies Congrats to all authors 🥳 Full text link: pubs.acs.org/doi/10.1021/ac… #nmr #SARSCoV2 #mainprotase #drugdiscovery

Our fragments-in-the clinic list is updated! At least 7 approved drugs started as fragments, with many more moving through clinical trials practicalfragments.blogspot.com/2024/02/fragme…