Review (PMID: 36742465 ) from Dr Sihem Boudina et al provided an outlook on the bi-directional relationship between cardiac mitochondrial dysfunction and myocardial structural remodeling in the context of metabolic heart disease, natural cardiac aging, HF.
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Dr Xander H. T. Wehrenset al commented on an article by Wagner et al. highlighted the need for more aging-related cardiovascular research and the importance of examining the role of various cell types, including neurons and ECs in the heart. PMID: 38235058
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This review from Dr. Gaetano Santulli et al. provided an updated overview of the functional role of #mitochondria in #cardiac #aging .
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The original Article from Dr. Dao Wen Wang et al. found an association between rare deleterious variants in the FBN1 gene and DCM in a Chinese Han population. They underline the importance of validating these results and elucidating the role of FBN1 in DCM
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This review from Dr. Catherine M. Shanahan et al. outlined the commonalities and differences in what is known about the genesis of calcification and amyloid, and highlighted key questions and areas that remain unknown and require further investigation.
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Dr. Na Li et al. commented on an article by Hulsmans et al. which highlighted the role of macrophages, especially the SPP1+ subset, in cardiac electrophysiology. SPP1 promotes AF via crosstalk between cardiac resident immune cells and non-immune cells.
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The Original Research Article from Dr. Georgina M. Ellison-Hughes et al. found the therapeutic potential of #senolytics D+Q in rejuvenating the reparative activity of human #iPSC -derived #cardiomyocytes and endothelial cells.
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Dr. Zoltan Arany et al. commented on an article illustrated how a specific omega-6 fatty acid in mother’s milk activates a transcriptional program for mitochondrial fatty acid metabolism in the heart to promote this early postnatal metabolic adaptation.
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This review from Dr. Paolo Calabrò et al. reviewed the current literature on the biology, pathophysiology, and therapies available and under development for #Lp (a).

Dr. Vihang A. Narkar commented on an article by Campos et al. which the work provides new tools and directions to understand the intertwining impact of #aging , #exercise , and #mitochondrial dynamics on physical fitness.
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Review from Dr Sakthivel Sadayappan et al assessed the pathogenic mechanisms that promote late-onset HCM through the lens of transcriptional, post-transcriptional and post-translational modulation of MYBPC3, underscoring significance in HCM across carriers
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Original Article from Dr. Dao Wen Wang et al. reassessed an estimated 500 putative genes in the Chinese Han population by whole exome sequencing to describe the landscape of variants in these genes and to confirm their genetic contribution to DCM and HCM.
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This review from Dr. Cody A. Rutledge explored the molecular mechanisms linking #sarcopenia and #HF , and to discussed treatment strategies aimed at addressing such molecular signals.
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Dr. William R. Lagor and Dr. Christopher J. Walkey commented on an article by Lebek et al. which the study demonstrated the potential broad utility of in vivo base editing as a #gene therapy for #heart disease.
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This review from Dr. Kenneth Walsh et al. focused on the association between environmental stressors and inherited genetic risk factors in the context of #CH development.
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The Original Research Article from Dr. Ali J. Marian et al. identified  #PANoptosis as a prominent phenotypic feature of #DSP cardiomyopathy and set the stage for delineating the specific molecular mechanisms involved in its pathogenesis.
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This review from Dr. Huaizhu Wu et al. provides a concise overview of the changes in lymphocyte populations within AT and their potential role in AT inflammation and the regulation of metabolic functions in the context of obesity.
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Dr. Hesham Sadek et al commented on an article by Lerchenmüller et al, the study highlights the role of exercise in myocardial renewal in the aging mammalian heart, supports the role of calcineurin in regulating the growth mode of mammalian cardiomyocytes.
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This new review from Dr. Stephen F. Vatner et al. examines the role of #brown adipose tissue (BAT) in mediating healthful #longevity .
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The Original Research Article from Dr. Ali J. Marian et al. concluded that cardiac fibroblasts contribute to the pathogenesis of #DCM - associated with #LMNA deficiency through activation of the senescence-associated secretory phenotype.
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