✨HTN challenge✨ You’re seeing a clinic patient with HTN (SBP 160) on valsartan 40 mg + amlodipine 5 mg, whom you diagnose with orthostatic hypotension (OH) What is your approach? 1/ Hypertension

⁦Steven Chen 陳持威, MD, MPH, MHPEd⁩ delivering ⁦Cleveland Clinic⁩ Hospital Medicine Grand Rounds! So excited to have him here today!

Our dream comes true: the #WATERFALLtrial has been published in NEJM Aggressive fluid resuscitation in acute pancreatitis is not safe & does not improve outcomes #GItwitter #SomosAEG Aegastro What's behind this publication? It all started 21 years ago nejm.org/doi/full/10.10…

Patients often have significant and reasonable concerns about pill burden and copays. Here's a quick 🧵 about combo oral diabetes medications I use:

This past Tuesday, I was honored to help plan and participate in what I think is the first ever clinicopathologic conference (CPC) with an artificial intelligence (Dr. GPT-4) discussant BIDMC IM Residency. It was… eerie... to say the least. These were my experiences: 🧵⬇️

Here’s a video I made breaking down this very important #ECG case of a young woman who presented to the ER with “heartburn” #FOAMed

Can GPT-4 solve really hard medical cases and come up with a good list of differential diagnoses? @zahirkanjee Byron Crowe and my study is out in JAMA , and the short answer is, “Yes.” But what does this all mean? 🧵⬇️ x.com/JAMA_current/s…

Here’s a video I made breaking down this deadly #ECG of a young woman who was resuscitated from cardiac arrest #FOAMed

To err is human. Our judgments are flawed. Our decision making is under constant assault. But there is something we can do about it. Read this 🧵to learn how “Decision Hygiene” can improve your judgment @SatyaPatelMD Prathit Kulkarni, MD @DxRxEdu Rabih Geha Rachel Goodman #IDTwitter

Today Avraham Z. Cooper, MD 🩺 and my essay on AI/LLMs and medical education comes out in NEJM , about the challenges our field faces and what we should do about it. I wanted to give some context for this essay, and talk about some of the things we can be doing NOW. A brief 🧵⬇️

1/ Day 2– #OW2023 A Tour De Force of Anti-obesity Pharmacotherapy: YOU DON’T WANT TO MISS THIS 🧵

8/ A Tour De Force of Anti-obesity Pharmacotherapy via Ania M. Jastreboff, MD, PhD … Day 2– #OW2023 Continued: Future of AOMs is getting “cray cray.” —Double and triple agonists (NuSHs) —MC4R agonists —Activin receptor inhibitors / myostatin blockers and more…

#idboardreview unimmunized child w/fever, cough, nasal inflammation followed 2 days later by diffuse nonpruritic maculopapular rash on face then chest then arms/legs. Exam: red conjuctiva, cbc, chem normal, chest clear, cxr b/l interstitial infiltrates #idtwitter #idxposts #meded

🚨#FLOW: The most anticipated trial of the year now published in NEJM with #ERA24 Semaglutide 1.0mg once weekly disease modifying with kidney, CV, & mortality benefits in people w T2D+CKD, cementing itself as a new pillar of care. 🧵 on key thoughts 👇🏾 nejm.org/doi/full/10.10…

What's a typical day in a GP practice in Denmark 🇩🇰 where 98%+ of people have access to primary care? Here's some of what I learned spending the day at a practice in Aarhus last month 🧵 (and yes, the space really is as beautiful as it looks in these photos!)

Our first RCT on using an LLM on diagnostic reasoning is out! And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans. What does this mean? A 🧵⬇️ x.com/EricTopol/stat…

Preprint out today that tests o1-preview's medical reasoning experiments against a baseline of 100s of clinicians. In this case the title says it all: Superhuman performance of a large language model on the reasoning tasks of a physician Link: arxiv.org/abs/2412.10849 A 🧵⬇️

There is a lot of buzz about our new paper in Nature Medicine on the effects of LLMs (GPT-4) on physician management reasoning! I had TONS of fun working on this -- but what it MEANS requires some unpacking. A 🧵⬇️ x.com/EricTopol/stat…

Huge update to our preprint today on the superhuman performance of reasoning models in medical diagnosis! TL;DR – they don't just surpass humans in meaningful benchmarks, but in actual medical care from unstructured clinical data: A 🧵⬇️: x.com/AdamRodmanMD/s…

Thanks to Eric Topol for highlighting our latest study, which looks at some of the failure points in the clinical reasoning performance of reasoning models. What does this mean for the future of diagnostic decision support? And can LLMs actually medically reason? A 🧵⬇️