Stokes lab superstars Autumn Arnold, Jeremie Alexander, and Gary Liu wrote a great review discussing the utility and limitations of AI for microbial natural product discovery. You can have a read here: thestokeslab.com/papers

Best #AMR scientists I've ever met.

I had the unique opportunity to write a piece for Maclean’s Magazine on the uses and limitations of AI in drug discovery. A lot of folks much more clever than me also wrote remarkably thought-provoking articles about the modern human experience with AI. macleans.ca/society/techno…

Congratulations also to Autumn Arnold of Jon Stokes' Lab! Autumn is the 2023 recipient of the Michael Kamin Hart Undergraduate Award for research into how AI can predict antibacterial activity in highly virulent and antibiotic-resistant bacterial pathogens.

@gerryiidr Dawn Bowdish John Whitney The 2023 Fisher Scientific Undergraduate Poster Award goes to Nathan Yuen of Lori L. Burrows' lab. Congrats also to our runners-up, Vian Tran and Isabelle Chan!

@gerryiidr Dawn Bowdish John Whitney Lori L. Burrows And last but certainly not least, the Global Nexus MSc Poster Award goes to Jeremie Alexander, a grad student in Jon Stokes’ lab! Congrats to runners-up Gary Liu and Brandon McMurray.

What is #AntimicrobialResistance? 👇 Understanding the global health threat with Jon Stokes, assistant professor McMaster Biochemistry & Biomedical Sciences and member McMaster IIDR. Global Nexus ow.ly/gj0E50QaLat

I’ve seen lots of chatter about the intersection of ML and biology. Hype? Probably some. But surely not all. Our ability to create good biological data and use it properly will determine our ability to transform biology into an engineering discipline through ML. Or not. I dunno.

From discoveries here on campus to a trip among the stars, it was a big year for McMaster researchers. Here are some of the stories that got people talking in 2023 🔗ow.ly/qKA450QkNiS

If you're interested in ADMET prediction for drug discovery, please check out ADMET-AI, a free, open-source AI platform for large-scale ADMET prediction that I built with Greenstone Biosciences and James Zou. See the thread for more details and try it out at admet.ai.greenstonebio.com!

A small AMR field is temporarily pretty awesome because I won't get scooped. But it's permanently pretty shit when life expectancy drops 20 years because we can't treat that little cut on your ankle. amrindustryalliance.org/mediaroom/drug…

🧪🤖 Super excited to share Synthemol: a #genAI that not only designs new molecule drugs but tells us how to build each molecule in lab. It designed 6 novel antibiotics that we synthesized in Ukraine and experimentally validated nature.com/articles/s4225… Nature Machine Intelligence 🧵

🆕Nature Machine Intelligence The WHO highest priority for a new antibiotic is for treatment of Acinetobacter baumanni. Then came this generative #AI: 13,500 compounds --> 6 novel, potent small molecules, easily synthesized nature.com/articles/s4225… Kyle Swanson Jon Stokes James Zou

More than 1 million people are dying each year from antibiotic resistance, considered a global health emergency. The pharma industry is doing little to respond. Thankfully academic labs, using A.I. and structure-based discovery, are kicking in. My summary Table of recent progress

In recent years, AI-guided drug discovery has led to the identification of new antibiotics; however, to this point, AI has not been harnessed to find novel antiviral molecules. Miller Lab and Jon Stokes seek to change that, and will use AI to target Influenza A virus.

The ESKAPE pathogens are a group of bacteria that are resistant to a wide array of antibiotics. Jon Stokes and Tracey Campbell are collaborating to develop an ensemble of molecular property prediction models to help increase the rate and decrease the cost of drug discovery.

Some of my hyper-brilliant students wrote a practical and fun Perspective in Nature Chemical Biology discussing the current state of the art of AI in early drug discovery. Find the PDF here and reach out if you'd like to chat! static1.squarespace.com/static/61d636d…