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We are very happy to share our lates publication in nature, spearheaded by Tal Givony &Yael Goldfarb, expanding the incredible cellular & functional diversity of mTECs and bringing key insights into the roles of thymic microfold and endocrine cells nature.com/articles/s4158…

With several recent advances and funding, Covid nasal vaccines now have momentum. It's covered in the new Ground Truths (link in my profile)

1/ We are excited to report in CELL the discovery and mechanistic exploration of human, X-linked recessive, complete MCST1 deficiency as a surprising genetic etiology of MSMD (doi.org/10.1016/j.cell…).

Amazing discovery by Casanova Lab Anne Puel & collaborators connecting inborn errors of immunity in alternative NF-κB pathway with thymic defects reducing mTEC AIRE expression leading to neutralizing Abs to type I IFNs & hypersusceptibility to viral diseases including COVID-19.

Thrilled to share our paper in NEJM on pre-COVID and SARS-CoV-2 negative MIS-C. This condition predates the pandemic but was incredibly rare and often misdiagnosed as Kawasaki Disease Shock Syndrome or Toxic Shock Syndrome without identified bacteria nej.md/49SwOTT 🧵

I am both delighted and honored to share the fruit of a wonderful thinking and writing exercise with @crow_lab. Injecting some human genetics (literally) and endocrinology (figuratively) into immunology might be refreshing 🙂 science.org/doi/10.1126/sc…

Have you wondered how Yamanaka found the 4-gene combination to transform somatic cells to stem cells? The # of possibilities are greater than - 20,000^4. I did this yesterday & read the original paper. What a journey & pure joy it was! Here’s how he did it. ⌛️

Just before the summer break! Very proud and excited to share our latest work on tumor macrophage ontogeny ! Spatial temporal regulation of TAM development revealed using time stamping approaches! Ms4a3 Creert2 is a gem! science.org/doi/10.1126/sc…, congratulations to the team!

On bioRxiv today, we raise serious concerns over a recent @nature paper describing ReDeeM, a new single-cell mitochondrial DNA (mtDNA) sequencing / analysis method. Here are three things that you need to know: 1/n biorxiv.org/content/10.110…

1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in nature about humans with inherited TNF deficiency: nature.com/articles/s4158….

1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in Science Magazine. science.org/doi/10.1126/sc… Here is a summary of what we discovered!

1/ Excited to share our latest publication in PNASNews! We report two patients with autosomal recessive RelB deficiency. Check out the thread for key highlights from our study! 🧵👇doi.org/10.1073/pnas.2…

The UMass Chan Medical School community celebrates Victor R. Ambros, PhD, recipient of the 2024 The Nobel Prize in Physiology or Medicine along with Gary B. Ruvkun, PhD, for the discovery of microRNA. WATCH Dr. Ambros’ first hours as a #NobelPrize winner: direc.to/mn9v University of Massachusetts Marty Meehan

A biomedical first: spatial biology used to find a lifesaving treatment! Just published nature Deep visual proteomics with #AI leads to effective JAKI treatment for 7 patients with toxic epidermal necrolysis nature.com/articles/s4158… Matthias Mann Lab Thierry Nordmann

Phenomenal paper, yet another human inborn error of immunity !

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: biorxiv.org/content/10.110… #Genomics #Epigenetics

*Attention all mucosal immunologists/microbiologists* Australian and New Zealand Society for Immunology Abstracts for #MIMS2025 in sunny Noosa are extended until the 6th of Feb Mucosal Immunology Society for Mucosal Immunology #sysmex QIMR Berghofer Don't miss out, amazing line up of speakers!👇

AAI is deeply alarmed by the planned termination of HHS employees, including vital workers at NIH, FDA and CDC. Diminishing this workforce undermines America’s leadership in science and technology and will have negative consequences for the economy. Every U.S. state benefits from

🧵 Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases. imprint.org/press-release-… With teams in Europe and North America, we are

Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto 🧵 1/ science.org/doi/10.1126/sc…