🔥 Latest systematic review and meta-analysis on #fluvoxamine and #Covid-19 ➡️ Fluvoxamine 100 mg bid is well tolerated and significantly associated with ⬇️ #mortality, #hospitalization, and composite of hospitalization/ER visits, but not at lower dose. sciencedirect.com/science/articl…

"Une enquête de SantépubliqueFrance a montré une hausse des épisodes de #dépression en 2021 dans toute la population ; Avec 1 #jeune sur 5 présentant des troubles dépressifs, la part des 18-24 ans touchés a quasiment doublé depuis 2017" | Pascale Santi lemonde.fr/sciences/artic…

American Journal of Therapeutics 2023 LETTERS TO THE EDITOR Antidepressants Are Associated With a Reduction in the Risk of Death in #COVID-19 Disease Patients. #Science #COVID19 #research #fluvoxamine journals.lww.com/americantherap…

⚠️ New large retrospective cohort study of #COVID-19 inpatients from Hong Kong during the Omicron period ➡️#FIASMA #antidepressants, specifically #fluoxetine, significantly associated with ⬇️ICU admission and ⬇️mortality, in both un/vaccinated people thelancet.com/journals/lanwp…

Impact of lithium on mortality among #olderadults with major #psychiatric disorders: A 5-year prospective multicenter study tandfonline.com/doi/abs/10.108… Nicolas Hoertel, MD, MPH, PhD

🔥 TOGETHER RCT 🔥 Treatment with oral fluvoxamine plus inhaled budesonide among high-risk outpatients with early COVID-19 reduced the incidence of severe disease requiring advanced care #IDTwitter acpjournals.org/doi/10.7326/M2…

👍 paper François Montastruc, MD, PhD Compared to AEs recorded in clinicaltrials.gov, 41.5% of serious AEs and 39% of non-serious AEs were not reported in the papers. The majority = psychiatric events + cardiovascular events. 94% of those = from esketamine groups. cambridge.org/core/journals/…

#Borderline personality disorder may be the psychobehavioral expression of a broader #coping strategy whereby individuals deal with early life #adversity by prioritizing immediate #reproductive goals over long-term somatic maintenance ones. jamanetwork.com/journals/jamap…

New retrospective cohort study of 116,498 individuals with #COVID-19: #antidepressant use among individuals with a psychiatric disorder is associated with reduced risk of #sepsis (p=0.033) and #death (p=0.026), confirming multiple prior cohort studies. nature.com/articles/s4138…

13/ Should we use PAX in 🏥 for hi-risk inpts who may progress❓While effective for OP, there is limited IP data and many pts w/ contraindications (medical cond’ns or meds)❗️ 🔸Paris cohort study, 62,525 pts 🔸14.6% (9136) had contraindications 🔸Older pts 27% vs younger pts 9%

🆕️⚡️Systematic review & meta-analysis #JAC 9 RCTs ~ 30K In a predominantly immunized population of COVID-19 outpatients, molnupiravir has no effect on mortality, probably none on ‘hospitalization or death’ and effects on symptom resolution are uncertain academic.oup.com/jac/advance-ar…

Enquête sur la piste négligée des antidépresseurs pour traiter le Covid. Un feuilleton en cinq épisodes publié cette semaine dans Factuel factuel.media/international/…