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Detailed characterization of Arabidopsis DAHP synthases revealed highly-complex regulation of the plant shikimate pathway. At least five different effector molecules (i.e. tyrosine, tryptophan, chorismate, arogenate, caffeate) feedback-regulate different enzyme isoforms.

Koper et al. (Yasuo Yoshikuni, Hiroshi A. Maeda) summarize the evolutionary history, diverse metabolic roles, reaction mechanisms & structure-function relationships of the AT family enzymes, w/an emphasis on their substrate promiscuity & multi-functionality. jbc.org/article/S0021-…

The Maeda lab discovered genetic mutations in plants that enhance the conversion of carbon dioxide into aromatic compounds. Read the story in UW News news.wisc.edu/altered-gene-h… and the paper in Science Advances science.org/doi/10.1126/sc…

UW-Madison is seeking outstanding candidates for a tenure-track assistant professorship involving fundamental research on plants, algae, or fungi in rapidly changing environments. Apply before Dec 31, 2022! nature.com/naturecareers/…

A new PNAS paper, by Maeda lab UW–Madison and Yoshikuni lab Berkeley Lab, revealed the evolutionary history of aminotransferase family enzymes, crucial for nitrogen metabolism, across the Tree of Life. Thanks to DOE Genomic Sci and NSF PGRP for support! tinyurl.com/yvn4wkju

Hiroshi Maeda lab UW–Madison seeks motivated and self-driven postdocs in evolutionary biochemistry & plant synthetic biology of aromatic amino acid & nitrogen metabolism. Graduating soon (next one year)? Check out and contact us! tinyurl.com/3rv45emd

The Luke Busta & Hiroshi Maeda labs together published our first “phylochemical map” The Plant Journal. Glad that our idea from 2017 PSNA meeting discussion at Missouri finally materialized, thanks to the hard work of many students during COVID and beyond! tinyurl.com/fj5ad9fv