Congrats to Meredith on a great summer internship in the Baran Lab and Cravatt labs! Came in w/o much synthesis and chem bio experience, left having made 8 new probes, analyzed them by chemoproteomics, and had a bunch of fun! Stay on the lookout, grad admission committees!

Interested in a more complete, honest story detailing our crazy + unreasonably lucky discovery that a "decomposed" thiourea can catalyze the Matteson homologation with high ee? Come read Jake's account of our work! thieme-connect.com/products/ejour…

🔵✨ Have a blue LED and wondering what to shine it on? Check out our latest code-free DFT tutorial and learn how to model UV-vis spectra of organic molecules 🌈🔬 👉 tinyurl.com/4uasu939 We test whether DFT can reproduce the puzzling trend below? 🤔

Lafayette Chemistry is excited to welcome our newest tenure-track faculty member, Assistant Professor Dr. Kristen DeMeester! Check out her bio: news.lafayette.edu/2023/08/29/kri…

When choosing PhD rotations, I’d suggest picking labs where the people are friendly and challenge your thinking. The research should motivate you, but don’t choose a lab for a specific project. This is a training experience. Your interests will change.

Over the past year, I've been learning about how quantum chemistry is used outside academia. (Turns out it's not just for "Figure 4" in JACS papers!) I summarize some of what I've learned here, and share some thoughts about how QM software should evolve to meet pharma's needs.

IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry! Support by sharing!

Interested in physical-organic mechanistic analysis? I watched this kid Dennis Kutateladze spend many many hours acquiring kinetics in his PhD… you should give his lecture a listen!

Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2 (Benjamin F. Cravatt and co-workers) Scripps Research UChicago Chemistry #OpenAccess onlinelibrary.wiley.com/doi/10.1002/an…

Still hungry to learn about physorg analysis after listening to Dennis Kutateladze? Let me teach you how to think about + conduct Hammett plot and KIE analysis! Feat. examples from my time in Jacobsen Lab. Thanks Synthesis Workshop for this sweet opportunity to share a passion!

Hayden Sharma is a KIE master and if you’d like to brush up on some important tools for mechanistic analysis, check out this awesome new lecture 🔥 Synthesis Workshop

Sweet paper by Jake Jacobsen Lab! In the first "intentional" application of our strange isothiourea boronate catalyst, Jake swaps out the alkali metal (from LIT Cat to KIT Cat) and uses it to catalyze an enantioselective Wittig. Incl kinetics, IR, and DFT pubs.acs.org/doi/10.1021/ja…

How do intrinsically disordered regions (IDRs) regulate protein function? Today in Molecular Cell, we show how the IDR of LSD1 acts as a fuzzy molecular switch to tune transcription factor interactions & control leukemia differentiation. (1/6) sciencedirect.com/science/articl…

Ton of fun working with Mike + Molhm Nassir on this paper! A "true" collab motivated by enabling better access to stereoprobes for chemoproteomics--for this paper and at least one more to come. Really exciting to be bridging the worlds of synthesis + chem bio!

Sweet work by Queen B Samantha Angle Jacobsen Lab on catalyst-ctrl'd iterative Matteson homologations! Feat. selective synthesis of all permutations of the stereotriad Benzestrol. Feel lucky to have been a small part of this story, Merck got a good one! pubs.acs.org/doi/10.1021/ja…

rowans funding announcement lines up well with the final clip subject: how did Rowan start? usually this leads to a boring answer but not in this case imo 'This is what we were waiting for. We were just totally on the wrong tech tree.' full link: owlposting.com/p/can-ai-impro…

We know DFT is slow. But how slow is slow? Corin Wagen went through and compiled a list of supercomputer usage statistics that were previously buried in government websites.

Excited to see our latest work in print! Total chemical synthesis of full length myoglobins, including mutants outfitted with a variety of noncanonical AA, for enantioselective biocatalysis: pubs.acs.org/doi/10.1021/ja…

Excited to share this work profiling a new P(V)-electrophile using our stereoprobe platform, where we discover a first-in-class, cell-active inhibitor of integral membrane protein TLCD1 and ID critical catalytic residues! Great collab w/Baran Lab biorxiv.org/content/10.110…

I’m happy to share that I’m starting a new position in med chem at Neurocrine Biosciences Biosciences! Feels wild to bring a 10-year chapter of academic research to an end, but I am excited for what the next will bring!