New TYP lab paper out today in Neuron led by PhD student Alex Lish! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! cell.com/neuron/abstrac…

Fu lab attended OSU #2025DepartmentofNeuroscienceResearchDay. Postdoc Marie-Amandine Bonte gave a great talk. Graduate student Tae Yeon Kim and Undergraduate James Xiao won the second place Poster awards. Nick, Sheeny, Jia, Mia, and Ethan presented their great Posters! Congrats!

Thrilled to share invited review with the brilliant NetaRosezweig! in the Immunity special issue on neuroimmune interactions. We explore shared immune pathways in Alzheimer’s & AMD, and chart new directions for cross-disease therapeutic strategies. cell.com/immunity/fullt…

🚀 BrightFocus is fueling the future of science. Today, we announced that we’re investing nearly $13 million in 50 bold new research projects to fight Alzheimer’s, macular degeneration, and glaucoma. These groundbreaking studies span 10 countries and focus on earlier detection,

🧠 Check out our new paper in Alzheimer's & Dementia Journals exploring how tau depletion improves vascular amyloid‐related deficits in a mouse model of CAA Thanks to Alzheimer's Association The Rainwater Charitable Foundation NIH Funding for supporting this work! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Excited our recent work is now in print in Cell! Why does tau protein impair memory in Alzheimer's? We show that high-molecular-weight tau from patient brains disrupts neuronal bursts by suppressing CaV2.3 calcium channels. cell.com/cell/fulltext/…

📢 Meet our newest grant recipients across Alzheimer’s disease, macular degeneration, and glaucoma research! These exceptional investigators, selected for their potential to bring us closer to cures by pursuing the untried, the unexpected, and the most promising ideas,

Happy to co-author another new paper today in Science Translational Medicine with our close friend and colleague, Tae-Wan Kim on TREM2 and its role in Alzheimer’s disease. science.org/doi/10.1126/sc…

Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease science.org/doi/10.1126/sc…

Thank you, Sen. Tammy Baldwin, for standing with the Alzheimer’s and dementia community by being a leader in the bipartisan effort to increase Alzheimer’s and dementia research funding at the NIH.

Congratulations to our #AAIC25 ISTAART student and postdoctural poster competition winners! 🔬 Fernanda Barros-Aragão 🔬 @kangmspeter 🔬 @lidia_vaque 🔬 Tae Yeon Kim 🔬 Lara Huyghe 🔬 Eden Mancor

Thank you #AAIC2025 for your great support for our talented young scientists who are interested in Alzheimer’s disease. Congratulations on all Poster competition winners, including my fantastic PhD student, Tae Yeon Kim. So proud of you!!!

Repeated head trauma causes neuron loss and inflammation in young athletes nature nature.com/articles/s4158…

Next Friday! Jonathan Godbout, PhD & Lynde Wangler, MS present #NTRIPS: “Unique profiles of microglia persist in the cortex after TBI that influence immune reactivity and neuropathology”. You dont want to miss this! Learn more: go.osu.edu/cbiactivities #CBI

Our study Immunity uncovered rod-shaped microglia as key responder to cortical hyperactivity in TDP43 neurodegeneration. These specialized microglia align with dendrites, remodel synapses, and provide protection via TREM2 signaling. Thanks Manling Xie for the leading efforts!

Happy to announce the YuTorontoLab's ( Pharm & Tox) latest paper, published in Molecular Neurodegeneration #sleep #proteostasis #autophagy #openaccess

📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs Irene Faravelli and @bolanosAnton 👩🏻‍🔬👩🏼‍🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇

Alzheimer's disease–associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell–derived microglia‐like cells alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

Our glial circadian atlas in AD and aging mice is now out in Nature Neuroscience! Congrats to Pat Sheehan for incredible work and to our collaborators John Fryer, PhD, Dougherty Lab WashU, Darshan Sapkota, Ron Anafi, and the team. John Fryer, PhD and I started this in 2019! nature.com/articles/s4159…

We are pleased to share our newest publication from the Blurton-Jones Lab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" sciencedirect.com/science/articl…