My 1st first-author manuscript is out in eLife - the journal! This project started back in 2019 with the question “what makes a viral protein evolve a new function?” A thread: doi.org/10.7554/eLife.…

The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to the present day. elifesciences.org/articles/83893…

Congrats to our student Cameron Durfee and his preprint on #bioRxiv He demonstrates human APOBEC3B can drive tumor formation in vivo. Check out this beautiful story below!

Don't miss the latest work from our PhD student Arad, his gain-of-signal assay is prominently featured in Science Advances science.org/doi/10.1126/sc…

Beautiful story by our very own Jordan B and student Ashley Auerbach Congratulations on the cool discovery!

Congratulations to Dr. Amanda Rieffer for a successful PhD thesis defense last Friday! We wish her the very best in all future endeavors!

Check out the latest publication from PhD student Jordan Naumann! She utilizes the hydrodynamic FAH delivery system to show "DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo" mdpi.com/2312926 #mdpiijms via IJMS MDPI

Don't miss the great work by members of our virus team this year at ASV! Elisa is sharing her poster at 8:30 PM at P22-23 and Ashley's work can be found at P10-8. #ASV2023 #LoveVirology

Big news from Midwest AViDD Center featuring Elisa Fanunza Yogesh Gupta and Shaun Olsen

Happy to share our last findings on HCMV evasion of APOBEC3 restriction!🤩 Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism | Journal of Virology journals.asm.org/doi/10.1128/jv…

Congratulations to Arad and Sofia for defending their respective PhD theses! This marks the official sunset of the Minnesota Harris Lab. We wish them the very best in their next steps!

Excited to share that our paper was officially published in Molecular Cancer!👇 Read more about EYA4 and its role in promoting breast cancer progression and metastasis here: rdcu.be/dnzkx A big thanks to DrayLab and fantastic collaborators Romain Tropée and Pascal Duijf.

I am excited to announce the publication of our manuscript out today, with Philippe Gui, Charles Swanton, Swanton Lab, Bivona Lab, @Downwardlab, and The Harris Lab! 🧵 1/15 nature.com/articles/s4158…

📣 Hot off the press! @NAR_Open Delighted to share our latest work! Thanks to all collaborators and contributors.

We thank our program committee for creating a great #SABCS24 lineup. VIRGINIA KAKLAMANI Carlos L. Arteaga, M.D. BalkoResearchLab Thelma Perry Brown @heide_ford The Harris Lab Tari King MD MarleenKokLab Adrian Lee Julia Maués Heather McArthur, MD, MPH, FASCO Dr. Patt Christos Sotiriou Antoinette Tan, MD, MHSc, FACP, FASCO Neil Vasan Ada Waks Antonio Wolff, MD (#HealthPolicyIsEconomicPolicy) Margaret Foti, PhD, MD (hc)

What a great way to start the day. This superb work from the Pillai lab, driven by Prajwal Boddu and a little help from us Bárbara de la Peña Avalos is finally in print Molecular Cell Highlight: SF3B1 oncogenic mutations reduce RNAPII gene-body elongation rate. sciencedirect.com/science/articl…

🚨 APOBEC3B (A3B) is a major source of🧬mutation in cancer The active site is like Teflon (not much binds) BUT Ozlem Dmr discovered a druggable allosteric site 👀 Experiments by Dan Harki Katherine Jones The Harris Lab 💪 biorxiv.org/content/10.110…

Carcinogens in tobacco smoke leave the genome vulnerable to deamination by viral restriction factor APOBEC3B. This new pattern of mutations known as “Didyma” can help delineate the origins a different cancers. Check out the full Pre-Print here: biorxiv.org/content/10.110…

Great representation at the 1st Annual Biochemistry Research Day at UTSA.

So excited to share our latest work with Sarat Chandarlapaty, Antonio Marra, Andrea Gazzo Memorial Sloan Kettering Cancer Center out today in Nature Genetics! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/ nature.com/articles/s4158…