New preprint: We predict treatment relapse in multiple myeloma using a hierarchical Bayesian model of sensitive and resistant population dynamics. Model was trained and tested on 229 patients from the IKEMA trial. medrxiv.org/content/10.110… Even Moa Myklebust @[email protected] Oslo Centre for Biostatistics and Epidemiology #mathonco

See our recent review, in a special issue edited by Stefano Santaguida from Joana Andrade Annie Dinky Gallagher and Jovanna Maharaj 'Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies' link.springer.com/article/10.100…

If you are interested in discovery research in cell biology of extracellular vesicles (EVs), we have an exciting ARC funded project for a domestic PhD student. More details here: unisa.edu.au/research/degre…
Please retweet ANZSCDB Centre for Cancer Biology ANZSEV Yoon Lim

Excited to be part of this massive international effort, leveraging the power of artificial intelligence in small molecule discovery. Centre for Cancer Biology UniSA Atomwise nature.com/articles/s4159…

Proud to have contributed to the new Human Genetics Society of Australasia predictive genetic testing guidelines led by Dr Danya Vears and co-authored by Alison McLean and Chloe La Spina

🧬 Please re-share 🧬

My lab is hiring postdocs to study aneuploidy's role in cancer! We're applying next-gen chromosome engineering approaches to uncover how gene dosage imbalances impact drug sensitivity, metabolism, immune evasion, and more.

Send me your CV+cover letter if interested. Please RT!

New #mathonco paper out, led by the optimal control genius Tuğba Akman “Modeling of mouse experiments suggest that optimal anti-hormonal treatment for breast cancer is diet-dependent” link.springer.com/article/10.100… Arnoldo Frigessi Vessela Kristensen Oslo Centre for Biostatistics and Epidemiology

🧬🔬We have a fully funded postdoc position. Details below. Please get in touch for more details!!

Are you interested in combining data-driven modeling with knowledge-driven modeling? Don’t miss our review of mechanistic learning in mathematical oncology frontiersin.org/journals/immun… Sarah Brüningk Paul Macklin John Metzcar Catherine Jutzeler-Walter #mathonco Oslo Centre for Biostatistics and Epidemiology

Happy to announce our new preprint Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer biorxiv.org/content/10.110…

nature.com/articles/s4146…

Come on, sit down, take a cookie, and learn about *scAbsolute: measuring single-cell ploidy and replication status* led by Michael Schneider

genomebiology.biomedcentral.com/articles/10.11…

We’re hiring! If you love developmental biology, mechanotransduction and transcriptional regulation of cell identity, we’d love to talk to you! Two positions are available to lead projects defining the roles of FAT4 and the Hippo pathway in lymphatics! 👇 workingatunisa.nga.net.au/cp/index.cfm?e…

Congratulations to Eleonore Toufektchan and all co-authors on our new study showing how TREX1 guards against anti tumor immunity by degrading cytosolic DNA to limit cGAS-STING! Great collaboration with the Samuel Bakhoum lab.

Just out!
Spoerri, Beaumont, Anfosso, Ryan Murphy, Alex Browning, Gunasingh, Haass
Real-time cell cycle imaging in a 3D cell culture model of melanoma, quantitative analysis, optical clearing, and mathematical modelling. Methods Mol Biol 2764: 291-310
link.springer.com/.../10.1007/97…

We are hiring an #engineer in the field of #molecular_biology to work with #single_cell_RNA_sequencing and #spatial_transcriptomics in the context of #breast_cancer research. Apply here: finn.no/job/fulltime/a…

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Today I'm happy to share our work on tumor karyotype selection, explored experimentally in Stephen Elledge's lab!

nature.com/articles/s4158…

Dear Brisbane friends: One of the people I am supervising in Brisbane is looking for a roommate – from this weekend onward! Please DM or email me if you know of anyone who may be interested. 🙏

Very happy to announce our first full paper from the laboratory in Molecular Oncology journal.
This is the result of a multidisciplinary collaboration with the pharma company Eli Lilly and Company (Madrid hq), the MD Anderson Madrid hospital in Madrid, and our academic institution CSIC.
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Amazing new work from the Pickett lab hildapickett and collaborators! This story on #EYA #phosphatase is gorgeous, complex, well done Hilda and everyone in the lab for getting it published! Can't wait to collaborate again and share the follow up stories nature.com/articles/s4146…