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Atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides to regulate their availability for classical opioid signaling. LIH_Luxembourg go.nature.com/2VapYUL

BPS Publications bpspubs.onlinelibrary.wiley.com/doi/full/10.10…

The tRNA epitranscriptome may play a regulatory role in immunity and haematopoiesis The American Association of Immunologists (AAI) Journal of Experimental Medicine Université de Liège giga.uliege.be/cms/c_6779989/…

Lambert lab's first preprint! Here, we identified coupling profiles between understudied orphan receptors and G proteins/arrestins without activating ligands. Impressive examples include high constitive coupling for GPR82-Gi and GPR182-Arr (~10 pubs for each receptor)

[📌New article from the research group "Immuno-Pharmacology and Interactomics", led by Dr Andy Chevigné] The Atypical #Chemokine Receptor ACKR3/CXCR7 is a Dual Scavenger for Adrenomedullin and Proadrenomedullin N-Terminal 20 Peptides (PAMPs). 📄 bit.ly/3lKyJ44 #arrestin

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7 | ACS Pharmacology & Translational Science pubs.acs.org/doi/10.1021/ac…

Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells advances.sciencemag.org/content/7/19/e…

The team of Jean-Claude Twizere publishes a study in Science Advances that may have a major impact in the understanding of the internal dynamics in an animal cell. Université de Liège F.R.S.-FNRS giga.uliege.be/cms/c_7459157/…

The natural analgesic #conolidine targets the newly identified opioid scavenger ACKR3/CXCR7 (LIH_Luxembourg and RTI International) 📄 go.nature.com/3fRzIhL #GPCRs #pain #opioids #ERNESTnetwork #chemokine #arrestin #ResearchLuxembourg

nature.com/articles/s4142…

Another exciting talk on our favorite area as Claudia Stäubert will discuss her work on biased signaling of metabolite-sensing GPCRs DrGPCR Summit 2021! Come join us #gpcr #drgpcr Domain Therapeutics Twist Bioscience #GPCR_Therapeutics Montana Molecular eventbrite.com/e/166176493365

Our new paper is online now as pre-proof: Succinate receptor 1 inhibits mitochondrial respiration in #cancer cells addicted to glutamine. Great work Philipp Rabe and everybody else involved sciencedirect.com/science/articl…

GIGA Doctoral School : new call ! Passionate about research ? You want to start a PhD in Biomedical Sciences in an interdisciplinary center ? Apply to start it in October ! gigadoctoralschool.uliege.be/application

Michael Herfs' team (Lab for Experimental Pathology, GIGA-Cancer) demonstrates in Nature Communications that, by drastically inhibiting innate immunity, human papillomaviruses (HPV) promote the development of bacterial vaginosis. Université de Liège ULiège Research & Innovation giga.uliege.be/cms/c_8948788/…

Check out our #review on #SREB: authors.elsevier.com/c/1fChmbEXZTV-… Thanks to the initiative by Julien Hanson we put together this summary of studies on this understudied family of #GPCR and provide perspectives about future directions. Thanks to all other involved.

Divergent effects of CXCR3 isoforms - N-terminal extension of CXCR3-B modifies its cellular localization and prevents G protein coupling #gpcr #drgpcr Subscribe to the Dr. GPCR Newsletter Today! DrGPCR.com/Newsletter bit.ly/3zLPdBY

Giving ERK a jERK from the endosome New Spotlight article from Evi Kostenis, Sergi Bravo, & Jesus Gomeza highlighting nature research article on non-canonical β-adrenergic activation of ERK at endosomes by Jin Zhang Lab Department of Pharmacology, UCSD cell.com/trends/pharmac…

Beware the Receptor Variants | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

GproteinDb update brings new G protein- #GPCR couplings, AlphaFold2-multimer models, interface interactions and coupling selectivity analysis doi.org/10.1093/nar/gk…

Keen to work on orphan GPCRs through cryo-EM? We are looking for a postdoctoral researcher.