A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer clincancerres.aacrjournals.org/content/early/…

Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression loom.ly/tlcMTMw

A Mesenchymal Cell Niche in Skin for Acute Myeloid Leukemia biorxiv.org/content/10.110…

Characterization of Bone Marrow Niche in Chronic Myeloid Leukemia Patients Identifies CXCL14 as a New Therapeutic Option ashpublications.org/blood/article-…

Skin mesenchymal niches maintain and protect AML-initiating stem cells rupress.org/jem/article-ab…

Skin mesenchymal niches maintain and protect AML-initiating stem cells, say Lakshmi Sandhow (Lakshmi Sandhow), Hong Qian (HONG QIAN) and colleagues Karolinska Institutet: bit.ly/3OdbA8W #Leukemia 🎥 See video summary by Sandhow: youtu.be/R_FVDBQ4zmg

.Lakshmi Sandhow, HONG QIAN et al Karolinska Institutet reveal the characteristics and previously unrecognized roles of skin mesenchymal niches in maintaining and protecting AML LSCs during chemotherapy bit.ly/3OdbA8W 🎥 Video summary by Sandhow: bit.ly/3OEY0No #Leukemia

Nice to see this! Thanks to ⁦⁦Mesenchymal Cell News⁩ app.e.stemcell.com/e/es.aspx?s=18…

Skin mesenchymal niches maintain and protect AML-initiating stem cells app.e.stemcell.com/e/es.aspx?s=18…

Skin mesenchymal niches maintain and protect AML-initiating stem cells, say Lakshmi Sandhow (Lakshmi Sandhow), Hong Qian (HONG QIAN) and colleagues Karolinska Institutet: bit.ly/3OdbA8W #Leukemia 🎥 See video summary by Sandhow: youtu.be/R_FVDBQ4zmg

HSCs are also more radiosensitive than many other types of cells, possibly because of their rate of division and lack of differentiation. This radiosensitivity, which has been shown repeatedly in accidental and intentional human exposures, is an important part of our story./4

My longtime friend Bob Gale & 2 radiobiology expert colleagues (James Welsh & P. Andrew Karam) recently published a paper Leukemia Journal highlighting how “ontogeny recapitulates phylogeny”, with migration of embryonic hepatosplenic hematopoiesis to adult hematopoiesis in marrow./16

Can anyone tell what those cells are? They are FACS sorted CD45lowCD31+ cells from the BM stromal cells enriched by CD45 and CD235a micro beads negative selection.

Monday January 22nd at 16.00 CET we will start our first Rotterdam virtual Hematology lecture in 2024! We have Els Mansell, from Erasmus MC and Lund University with: "The impact of mitochondrial state on hematopoietic stem cell fate". Link: us06web.zoom.us/j/83009472100

Interested in leukemia niche? Welcome to join us! ki.varbi.com/en/what:job/jo…

Leukemia niche – Hong Qian group ki.se/en/research/re…