In 2020, Steven Banik & Carolyn Bertozzi introduced LYTACs, a way to degrade surface & extracellular proteins. In a new study, 1st author Green Ahn and team maps the degradation process, which could lead to new therapies for Alzheimer's, cancer, & more: stanford.io/3smOMgc

Check out this write up on Green Ahn's recent paper Science Magazine! Thanks to Jen Miller for making the work accessible for a broad audience! Sarafan ChEM-H Carolyn Bertozzi
news.stanford.edu/?p=48903 via @Stanford

It was amazing to watch Green Ahn power through this project. Many challenging experiments, cool data to sift through, follow-up experiments to pin down, and thoughtful interpretations to flesh out. She was fearless and uncovered fascinating insights into lysosomal degradation.

Congratulations to PhD graduate Green Ahn and the team on this insightful work shedding light on the cellular machineries contributing to #LYTAC -mediated degradation of membrane-associated proteins, great collaboration with Sarafan ChEM-H Stanford Chemistry colleague Steven Banik

Elucidating the cellular determinants of targeted membrane protein degradation by lysosome-targeting chimeras | Science science.org/doi/10.1126/sc…

Thank you to the amazing Green Ahn for letting me contribute to this amazing work in Science Magazine!! Thank you also to Carolyn Bertozzi for hosting me in her lab whilst working on it and to the rest of the collaborators for making it happen!

Amazing work driven by Green Ahn blazing new trails for LYTACs and beyond in Science Magazine. Membrane protein degraders can be used as a new lens into fascinating cell biology which impacts their therapeutic applications. Great to collaborate with Carolyn Bertozzi as always!

Excited to finally share what I’ve been working on for the last few years! 🚋Targeted Relocalisation Activating Molecules(TRAMs) 🚋 that hijack endogenous transport pathways to relocalise proteins to different subcellular spaces, including axons!

Excited to share this work from Christine Isadora Ng! Precise control over protein subcellular localization could have massive implications for gain-of-function therapeutic strategies. We showcase targeted relocalization activating molecules (TRAMs) for rewiring interactomes. (1/n)

The Stark Lab MIT Dept of BE and Koch Institute at MIT opens January 2024! We are recruiting curious and motivated scientists at all levels.
Learn more about our work and how to join our team: jstarklab.com 🧬
Please share widely! #immunoengineering #synbio #glycotime #newPI

Phil Leung and I are excited to see our work on multistate design of hinge proteins finally published as a peer-reviewed paper
science.org/doi/full/10.11…

Congratulations collaborative team lead equally by
⁦Gabby Tender⁩⁦Kayvon Pedram⁩ and ⁦Judy Shon⁩, w/coworkers from ⁦Heinz Läubli⁩ and Weaver labs. Mucins drive cancer progression; we drugged them with targeted mucin proteases. nature.com/articles/s4158…