I’m very excited to share my PhD work on how age impacts tumor development and suppression. A huge thank you to Monte Winslow's Lab, Dmitri Petrov and all the co-authors for their support, wisdom, and patience (aging takes time!) over the past 5+ years. biorxiv.org/content/10.110… (1/n)

Exciting news: Yuping Li and David Brückner (David Brückner) have been appointed as new Assistant Professors Biozentrum, University of Basel University of Basel. Li studies bacteria-jumbophage interactions, and Brückner explores the dynamics of multicellular systems. ow.ly/UlqP50StwWV

How do healthy tissues evolve to become cancerous? Delighted to share our latest research tracking the somatic evolution that occurs in the decades before AML. 👇Implications for early detection and early interception. biorxiv.org/cgi/content/sh…

Now out in MBE! Fitness assays often involve barcoding, but barcode-dependent amplification bias can cause fitness misestimates. We present a method to detect/remove such bias with no changes to the exp. protocol. doi.org/10.1093/molbev… Ryan Seamus McGee Grant Kinsler Dmitri Petrov 1/2

Excited to share our new bioRxiv in which we demonstrate the formation and maintenance of cellular memories in melanoma during acquisition of therapy resistance - dependent on the transcription factor AP-1 biorxiv.org/content/10.110… (1/9)

Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

Join us! The Machado Lab at Cambridge University is looking for an enthusiastic RA to be a core member of the team and lead the lab's data generation efforts, seeking to understand how tumour and immune cells co-evolve and contribute to cancer progression. jobs.cam.ac.uk/job/47922/

Is there more than one mechanism underlying resistance to an antifungal drug? How many mechanisms are there? Kara Schmidlin and Sam Apodaca explore these questions in their paper out today in final form at eLife - the journal! elifesciences.org/articles/94144 (1/9)

Immune surveillance of cancers is thought to be an important force shaping tumour evolution. Is the same true of somatic evolution in general? Does the adaptive immune system “see” non-self clonal expansions and eliminate them? A:👇 by Babrara Walkowiak biorxiv.org/content/10.110…

It looks like I never posted anything (*but see below) on what are probably the most surprising results my lab obtained so far. Anyway, this work—led by an outstanding former PhD student Sarah Ardell in collaboration with Milo Johnson—is now published: science.org/doi/10.1126/sc…

New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30

Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…

Thrilled to share that I'm starting my own lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! My lab will study how microbes interact and evolve in complex communities like the human gut microbiome. kxuelab.com 1/2

Two stages of evolution... Grant Kinsler Gavin Sherlock Dmitri Petrov use #ExperimentalEvolution in yeast to show that while 1st-step mutants appear pleiotropic in nature, 2nd-step mutations show a shift towards modular adaptation #PLOSBiology plos.io/4glXoXJ

How blood ages - A curious case of mice and men. Our latest study nature published today. Biological processes such as DNA mutagenesis often scale to animal time. Blood stem cells have special evolutionary protection against this. 👉🏽nature.com/articles/s4158…

Excited to share our new work on the distinct drug sensitivity profiles of heterogeneous therapy-resistant melanoma cells! Arjun Raj biorxiv.org/content/10.110… (1/10)