Ever wonder wonder why prostate cancer cells become heterogeneous with treatment? Alexandre Germanos from Hsieh Lab did for his Seattle MCB Program PhD work and it is so great to see his paper accepted and out today in @eLIFE (elifesciences.org/articles/79076). Check out his tweetorial too!

Thrilled to share my views as a new PI!

Very excited to share our pre-print exploring the genomic landscape of lung cancer in post-menopausal never-smoker women from the Women’s Health Initiative study Alice Berger Gavin Ha Fred Hutchinson Cancer Center

Thanks for highlighting this work on tumor subtyping from ctDNA. Congrats also to Navonil DS RobertPatton AnnaLisaDoebley and many collaborators Fred Hutchinson Cancer Center Dana-Farber Daniel Stover, MD, FASCO

Can an integrative approach reliably detect urine tumor DNA in localized #bladdercancer patients? We addressed this in our latest paper, out now in @Nature_npj Precision Oncology. nature.com/articles/s4169… Zachary Smith WashU Urology Wash U Radiation Oncology WashU Liquid Biopsy WU Division of Physician-Scientists 1/15

We have an open joint-postdoc position with DavidMacPherson to work on new computational approaches for studying #lungcancer using #liquidbiopsy. If you're interested in cancer genomics, LBx, AI or #PrecisionOncology, pls apply! careers-fhcrc.icims.com/jobs/24533/job

📢Prostate Cancer Scientists (PhDs, MD/PhDs, or MD scientists) - join us at Fred Hutch! New lab-based PC position (wet or dry) posted! bit.ly/3Ela8gN Email Pete! (pnelsonFred Hutchinson Cancer Center.org) PCF Science Hsieh Lab Lee Lab Burcu Darst Daniel Lin @fredhutch Petros Grivas

Faculty position opening! Assistant or associate faculty professor in the Fred Hutchinson Cancer Center Prostate Cancer Research Program! Broad research expertise considered (e.g., prevention, genetics/genomics, therapeutics): bit.ly/3Ela8gN New PI Slack Future PI Slack #prostatecancer

Recently published: @gavinha et al. develop Griffin, a #computational framework for #tumor subtype classification based on #cfDNA #nucleosome profiling that can work with ultra-low pass #sequencing data #CancerResearch @natrescancer doi.org/10.1038/s41467…

In the March issue of Cancer Discovery— Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes, by Navonil DS, Robert Patton, Peter Nelson, Gavin Ha et al bit.ly/3mXpBhc Fred Hutchinson Cancer Center #LiquidBiopsy #cfDNA #ctDNA

Fred Hutch is recruiting a faculty member for our #prostatecancer research program. Focus areas include primary prevention, etiology, genetics/genomics, epigenetics, tumor microenvironment, metastasis, development of novel therapeutics and more. Apply: apply.interfolio.com/121588

Excited to share our paper Nature Communications on STEAP1 CAR T cell and tumor-localized IL-12 for prostate cancer: tinyurl.com/2ze4trzt Congrats to lead author Vipul Bhatia! Thanks to our collaborators Jun Ishihara Saul “Cancer Asskicker” Priceman Shivani Srivastava Fred Hutchinson Cancer Center Institute for Prostate Cancer Research PCF Science.

Attending the Major Symposium at #AACR23 about Liquid Biopsy? See the related paper published in Cancer Discovery: Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced #ProstateCancer Phenotypes by Gavin Ha and Navonil DS aacrjournals.org/cancerdiscover…

Excited to share our recent work on KaryoCreate, a new method to engineer chromosome-specific gains and losses in human cells with Stefano Santaguida and Giunta Lab cell.com/cell/pdf/S0092… Check out also recent similar and complementary work by Susanne Lens and @McClellandLab!

Check out the Cancer Discovery papers highlighted in the new AACR Journals collection, Liquid Biopsies. bit.ly/3WP1E9M Gavin Ha

Have you ever wondered if 3’UTR point mutations found in cancer patients matter? We’re excited to share our new publication out today Cell Reports, where we’ve defined how prostate tumor 3’UTR mutations affect molecular & cellular oncogenicity. cell.com/cell-reports/f… 1/n

The #MahanFellowship supports young scientists in the early stages of their careers. We offer fellows a 21-month stipend as they pursue their proposed research project, alongside a mentor in one of our Herbold Computational Biologist labs. Apply today: apply.interfolio.com/130340

So excited to share our work on tumor genomes of African ancestry in common cancers. We report several actionable associations, including a novel ancestry-smoking interaction impacts TP53 rate. More discoveries to come if we improve diversity in genomics! cell.com/cancer-cell/fu…

Congrats to Robert Patton for being awarded the PCF Science 2023 Young Investigator Award & achieving the top scoring application! Honored to be his co-mentor with PeteNelson. #PCFRetreat23

In a step toward a #liquidbiopsy for small cell #lungcancer, a Fred Hutch team led DavidMacPherson and Gavin Ha have developed an approach that can distinguish several #SCLC subtypes from blood samples. bit.ly/3TUvFUr