Assessing target engagement using proteome-wide solvent shift assays biorxiv.org/cgi/content/sh… #bioRxiv

Our new review out on the Ligandability of E3 Ligases for Targeted Protein Degradation Applications by ⁦Bridget⁩ & ⁦Carl Ward⁩ in ⁦Biochemistry⁩ that includes our aggregate chemoproteomic data for cysteines in E3 ligases! pubs.acs.org/doi/10.1021/ac…

SCOOP: An insanely well-funded company called Altos Labs is going after "rejuvenation" technology. Yamanaka factors. Epigenetic clocks. CRISPR. Offering academics $1 million salaries and more. Investor rumor mill: Milner, Bezos, ARCH. Musk? technologyreview.com/2021/09/04/103…

Interesting: label recombinant E3s on Cys w/ maleimide + linker + target binder, electroporate into cells, see if degradation ensues. Complementary to covalent fragment screens. Eye-opener was that a tagged CRL adaptor (SKP1) also led to degradation. cell.com/cell-chemical-…

Big thank you to Battlefield Leaders and Colonel Kevin Farrell for an enriching workshop. Who knew long-ago decisions on the battlefield could have such relevance today? #leadershipmatters #oerthlings