In a nutshell, we showed that over-the-counter cheap generic antibiotic neomycin can be repurposed in nasal formulation to prevent & treat infection, block transmission, and reduce disease burden against a wide array of viruses. Since this is a host-directed strategy and

What about transmission? Hamsters trx 1 day earlier with neomycin were protected from catching the virus from an infected hamster in the same cage. Even if they did, their viral load was ⬇️. Thus, neomycin applied in the nose can shield the host from COVID transmission.

In our current study, we showed that nasal application of neomycin in mice one day before infection reduces viral load and disease burden after the SARS-COV-2 challenge. Tianyang Mao (3/)

Preventing infection is the best way to avoid diseases like #PAIS . A new study from our team Tianyang Mao, Jooyoung Kim, Mario Peña-Hernández 🦇 et al shows that a generic antibiotic neomycin acts on the host immune system in the👃🏽to trigger antiviral resistance. (1/)🧵

Our health care system is persistently overwhelmed and we have normalized libertarian attitudes toward health decisions that are antithetical to public health and care for the vulnerable. Canada’s social safety net is crumbling because we have failed to meet these challenges.

/4

Good results from Adam Wong's Airfanta Lite.
Fengrui air quality monitor 30cm from fan which was set to low speed. Burnt some tissue to create PM2.5 which was reduced to zero in around 1':30'

Even The Guy Doing More Health Stuff Than Anyone Else is still dealing with long-term COVID damage that resulted from “only” a mild infection.

So, I know this will sound conspiratorial, but I’m beginning to think there is a pact of silence around COVID-19 and long Covid as reasons for the record levels of sickness we’re seeing.

From the Government to the BBC and many commentators on this platform.

It’s dystopian.

I said I was going to put something together to explain the major points missing from Bernie's Long COVID plan...

And this time I actually did it.

My team really made this happen I was merely the vessel.

thepeoplesstrategist.com/p/bernie-sande…

Friends, just a reminder that in addition to the Paxlovid and Maraviroc/Truvada trials for #longcovid , there is ALSO the trial of Lau-7b in Canada.

It’s a combined Phase 2+3 trial, and the results are due THIS year.

clinicaltrialsarena.com/news/laurent-c…

Antivirals for long COVID

Mount Sinai is conducting two key clinical trials related to the treatment of Long COVID:

1. Trial of HIV antivirals Truvada and Maraviroc[1][2][3]:
- Researchers at Mount Sinai, led by David Putrino, are conducting a clinical trial to test whether

#Variant update for #Ontario , #Canada (to Apr. 9, 2024)

The regular BA.2.86.*/JN.1.* #Pirola clan of variants as you know them are starting to go down in Ontario. This is because descendants are picking up two very useful FLiRT mutations. Graph tools by Mike Honey 🧵1/

🧵Covid Variant Update
Ontario PHO is projecting strong growth of JN.1 offspring, JN.1.11.1 and its offspring KP.2. These include the 'FliRT' mutations S:F456L and S:R346T being found around the world including North America.

If you are interested in having the #Novavax Covid vaccine please like, share and comment on this post with a hashtag of where you are in the country (example #Bath ) - we will then share this with our partner pharmacies to help demonstrate public demand in their community 🙏

British doctors to be stripped of their power to sign people off sick from work. This is what happens when class/political interests, from the left to the right, quietly collude to end a pandemic without the virus that caused the pandemic actually going away

Imagine we can identify JN.1-neutralizing mAbs at the start of the pandemic, how revolutionary it would be for COVID mAb drug development. Here we provide a strategy to select potent SARS-CoV-2 broad-spectrum mAbs when we only know the ancestral strain.
biorxiv.org/content/10.110…

MEDIHONEY AND MĀNUKA HONEY EXTRACT INHIBIT THE ACTIVATION OF THE MAST CELL RELATED-G-PROTEIN COUPLED RECEPTOR X2 (MRGPRX2): POTENTIAL INTRAVESICAL USE IN PATIENTS WITH INFLAMMATORY BLADDER PATHOLOGY

auajournals.org/doi/abs/10.109…