linkedin.com/posts/franca-f…

CCPBioSim Biomolecular Simulation at this week's workshop Thanks to all the trainers that helped in making this a success! on #structuralbioinformatics resources and tools for #moleculardynamics simulations. The course is run in association with CoSeC UKRI and STFC.

sciCSR developed by Fraternali Lab, Josef Ng and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics. nature.com/articles/s4159…

Very happy that sciCSR - our new method in analysing B cell Class-Switch Recombination (CSR) in #scrnaseq data - is out Nature Methods - Tweetorial below 🧵

Very proud to finally see this recent work from my lab out in Nature Methods! Thanks to a fantastic collaborator like Josef Ng and an enthusiastic group of Immunologists! nature.com/articles/s4159…

Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub!

Xmas gift 🎁 came early for us: New review came out on Current Opinion/Research in Structural Biology where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at authors.elsevier.com/c/1iHZn,LqArQC…

Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM

Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with Fraternali Lab Mauri Lab UCL jobs.surrey.ac.uk/Vacancy.aspx?r…

We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7) 📄biorxiv.org/content/10.110… 🌐fraternalilab.cs.ucl.ac.uk/VCAb/

Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the IIT symposium 2024 🎉👏

Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024

Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024

Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024

Proud to be part of this exceptional mentoring programme💪 ELIXIR Europe

Happy to share new work Fraternali Lab led by Dongjun Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.

🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions biorxiv.org/content/10.110…

Another preprint Fraternali Lab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab franca fraternali Sophia Karagiannis biorxiv.org/content/10.110…

Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!