The #DasGuptaLab is hiring a postdoc to develop RNA-based tools for sequencing modified RNAs. Ideal candidates should have nucleic acid chemistry/biochemistry experience. Expertise in the ‘in vitro selection/evolution’ of nucleic acids is preferred. #chempostdoc RNA Club Tirupati

Using simulations, synthetic cells, and live archaeal cell communities, Andela Saric, Kerstin Göpfrich, and Buzz Baum are challenging the assumption that the cell membrane is passive and only changes shape when acted upon. #FrontierScience

We have been trying to figure out the mechanistic mysteries about SMC motor proteins. They extrude our genome constantly into loops. We know that that's important. But how it works, is a matter of intense debate! Today, we report a piece of the puzzle:

Out now in Nucleic Acids Res! A #ribozyme can self-integrate into and hydrolyze ss- & dsDNA, offering a new avenue for the development of protein-free genome editing tools, and hinting at the possibility of a pre-translation origin of group II introns (G2Is).🧵1/7 academic.oup.com/nar/advance-ar…

Congrats to Edward Gao on the publication of his paper - an improved synthesis of damaged pyrimidines - doi: 10.1080/15257770.2024.2437038

We finally posted a manuscript describing this tool predicting accurate 3D DNA mechanics from sequence and its applications to probe mechanical selection in diverse eukaryotic genomes. Led by Jonghan Park of Yonsei U with awesome help from collaborators biorxiv.org/content/10.110…

Still accepting applications for 2 fully funded PhD positions at the University of Warwick in ultrafast photonics and energy/quantum materials. Please share and get in touch (links/deadlines below) if interested! PhD 1: tinyurl.com/ykmaxvxy PhD 2: tinyurl.com/2j33xxac

Learn how homology search might work in 3D genome! We combine very fast CRISPR and Hi C to look at 3D genome changes during DNA repair and found that break anchored DNA extrusion by cohesin can help search for homologous sequences.

Check out our new preprint! Much of the RNA modification work to-date uses immortalized cells but how does immortalization actually impact RNA modification landscapes? Let’s dive in! biorxiv.org/content/10.110…

Amazing work from the HaLab, and this interplay between biophysical properties and genome organization are so cool! Congrats to Sangwoo and an amazing team.

Possibly the first comics poster in 30 years of the The RNA Society Meeting. Exploring the history of the RNA World with artwork from my collaborator arghya manna. Work funded by Notre Dame Global and Notre Dame Science .

Bringing the Genetically Minimal Cell to Life on a Computer in 4D biorxiv.org/content/10.110…

high-throughput single-molecule platform to study DNA supercoiling effect on protein–DNA interactions academic.oup.com/nar/article/53…