Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.

Nasal mucosa of children is characterized by often asymptomatic viral and/or bacterial infections that regulate distinct innate immune programs Journal of Experimental Medicine Ellen Foxman @TimothyAWatkins preview Ivan Zanoni: doi.org/10.1084/jem.20… doi.org/10.1084/jem.20…

The first tumor infiltrating lymphocytes (TILs) were FDA approved to treat refractory cancer (melanoma) this year. In the new issue Science Magazine a rundown and perspective from the pioneer who worked on developing this living drug for >30 years science.org/doi/10.1126/sc…

In this month's interesting fact about #glyco we learn how #monosaccharides not synthesized by humans/mammals could occur as part of the human/mammalian glycan repertoire. Read more: research.bidmc.org/ncfg/blog/fact… For more interesting facts check: research.bidmc.org/ncfg/interesti… #glycotime

Hoy recibimos el Registro Sanitario de Quimi-Vio, nuestra #vacuna antineumocócica conjugada, por el CECMED. En el Instituto Finlay de Vacunas, hemos trabajado en esta vacuna durante más de 15 años.¡Felicidades a investigadores e instituciones que han sido parte de esta bonita historia! 👏🎉

If you are convinced that microbes are causal of infectious diseases, please take a breath, and consider the alternative possibility that infection with a trigger microbe reveals a preexisting cause of disease in the host: annualreviews.org/content/journa…

Nature research paper: Inhibition of IL-11 signalling extends mammalian healthspan and lifespan go.nature.com/3WsaD1S

IL-11 is a cytokine induced with age, regulates an ERK–AMPK–mTORC1 axis which contributes to age-associated tissue decline (Inflammaging). Blocking it show health benefit in aged mice. Beautiful new work by Stuart Cook lab & collaborators at MRC Laboratory of Medical Sciences (LMS) nature.com/articles/s4158…

"Host control of the microbiome: Mechanisms, evolution, and disease" Science Magazine science.org/doi/10.1126/sc…

Brainwashing. We're learning more about how the glymphatic system achieves waste removal from the brain and preserves immune response (such as surveillance) integrity science.org/doi/10.1126/sc… Science Magazine by Jonathan Kipnis 💔🎗️

The World Health Organization has updated its list of most dangerous viruses and bacteria go.nature.com/46uc8jy

Humans are locked in an arms race with microbes, but scientists are pursuing diverse approaches to keep one step ahead or slow down the competition. go.nature.com/3yCG2FX

BCG vaccination alters gene expression and chromatin accessibility in hematopoietic stem and progenitor cells, predicting cytokine secretion in peripheral blood mononuclear cells Immunity Luis B Barreiro Sarah Sun cell.com/immunity/fullt…

🆕 Antimicrobial resistance poses an important global health challenge in the 21st century. A new in-depth global analysis suggests more than 39 million deaths from antibiotic-resistant infections could occur between now & 2050. Explore the data: buff.ly/3zlVE0U #AMR

By 2050, around 2 million people — the majority aged over 70 — could die from drug-resistant infections each year go.nature.com/4e8E9jO

Antigen presentation for central tolerance induction dlvr.it/TDPPdy

Transforming vaccinology: Cell cell.com/cell/fulltext/…

Understanding vertebrate immunity through comparative immunology dlvr.it/TDd5QM

This work adds to previous studies describing broadly antiviral antibodies. In general, they bind to conserved glycans that are unique or enriched on viruses, such as high mannose and other complex glycans. (13/) cell.com/cell/fulltext/… pubmed.ncbi.nlm.nih.gov/39292703/

A study explores how viral N-linked glycans play a role in the interaction between chloroviruses glycoproteins and key receptors of the innate immune system. Fabrizio Chiodo nature.com/articles/s4200…