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A 100-year-old drug might be a promising treatment for autism spectrum disorder! A small clinical trial recently revealed that Suramin, a drug originally developed for African sleeping sickness, seems to improve communication skills and social behaviors in individuals with

What does Nobel Prize Winner Dr. Drew Weissman think of drug repurposing? Like us, he thinks it’s a no brainer! Developing new treatments for diseases is costly, time-consuming and driven by profit. Novel drug development requires $1-2B and 10-15 years per drug, and has a 90%

When a drug receives FDA approval, its research and development (R&D) often shifts away from further exploration into new indications. It's a common misconception that approval marks the peak of a drug's journey. In reality, it’s the opposite. When the drug eventually turns

I'm excited to share that I'll be speaking at #AAMC24 on Nov 11 in Atlanta! Join me for a discussion with KizzyPhD about the pipeline from scientific discoveries to advanced treatments and optimal health for all. Learn more and register here: bit.ly/learnservelead…

Celine Dion got her voice back thanks to a repurposed drug! Diagnosed with stiff person syndrome, a rare disease that took away her ability to walk, talk, and sing, she fought an inspiring battle to regain her health. Through intense physical therapy and the use of IVIg, a

As a med student, David Fajgenbaum, MD nearly died several times from Castleman’s disease, a rare condition with no known treatment. After discovering his own cure, the Penn Medicine leader is now on a quest to help find treatments for others. ow.ly/favP50TuCwz

I am so honored to be accepting the WebMD Health Hero Award on behalf of my teams at Penn Medicine, CDCN, and Every Cure! Congrats to Regina Barzilay and Suchi Saria who also received the award!

Janet Woodcock, former FDA official, joins board of patient group focused on ‘rediscovering’ old drugs Woodcock + David Fajgenbaum, MD = ?????? statnews.com/2024/10/07/jan… via STAT

It was an incredible honor to accept the Vision of Hope Award at the 2024 Stand Up to Sarcoma Gala on behalf of my teams at Penn Medicine, CDCN, and Every Cure. Angiosarcoma hits especially close to home for me and my family, as my uncle was diagnosed with this

Injecting lidocaine directly into breast cancer tumors resulted in a remarkable 29% reduction in mortality, according to a large randomized control trial involving nearly 1,600 patients! Researchers estimate that this simple, accessible approach could save over 100,000 lives

I'm thrilled to announce that I'm hiring a Chief of Staff to work as my right-hand person across the three incredible organizations I lead. The official title is Director of Strategy and Business Development, and I’m on the lookout for someone: 🧬 Hungry to make an impact

What if a simple, affordable drug could unlock communication skills for children with autism? A significant number of children with autism may have cerebral folate deficiency due to auto-antibodies against the folate receptor, effectively blocking folate from reaching the brain.

A few days ago, we learned that the first patient in the U.S., to our knowledge, has been dosed with lidocaine for their breast cancer treatment. Just six weeks ago, we learned about the potential connection between lidocaine and improved breast cancer outcomes from a

Did you know a simple derivative of vitamin C is transforming the lives of children with congenital disorders of glycosylation? This breakthrough, led by Dr. Ethan Perlstein bio/acc and the CDG Cure Collective is helping kids experience fewer seizures and improved symptoms—an incredible leap

Every Cure Expands Collaboration with @GoogleCloud to Transform AI-Driven Drug Repurposing Every Cure will leverage @GoogleCloud’s infrastructure and AI technologies, including Gemini 2.0, to accelerate discoveries and improve patient outcomes. everycure.org/every-cure-exp…

What if a common amino acid found at your local health store could alleviate some of the worst pain imaginable for sickle cell patients? Patients with sickle cell disease often endure severe, life-limiting pain from vaso-occlusive crises caused by sickled red blood cells.

Thrilled to share that our work has just been published in the NEJM highlighting a life saved with a repurposed drug, adalimumab. nejm.org/doi/full/10.10… Through proteomics and cellular assays in my lab at Penn Medicine, we identified TNF signaling as a key driver of Castleman

Doctors are studying the low-cost drug leucovorin, derived from folic acid, as a possible treatment for autism in children. But with little profit potential, pharmaceutical companies won’t fund FDA trials — leaving families dependent on off-label prescriptions. Dr. Céline Gounder, MD, ScM, FIDSA 🇺🇦

We are thrilled to share that the The New York Times has just featured Every Cure and our work using repurposed drugs to save lives. Click the link below to read the full article! nytimes.com/2025/03/20/wel…