Our article describing a new faithful model of MLL-AF4 infant ALL is out today🎉Thanks to co-authors, funders, and patients/their faimilies for helping make this a reality! Hopefully this will be a powerful model to help understand this aggressive disease
nature.com/articles/s4146…

Massive congrats to Camille Malouf for her latest paper in Blood Journal! Patient microRNAs are missing in murine blasts and can be used to generate a new murine infant MLL-AF4 B-ALL model and much more. Grateful to have been able to contribute to this. doi.org/10.1182/blood.…

Chromatin accessibility profiling methods nature.com/articles/s4358… Huge multi-lab review

Even cancer cells have sex!
Our fresh paper on the matter nature.com/articles/s4155…

Why do some genetic disorders present in kids and others in adults? Our new paper w/@Magee_Lab reveals that BIG changes in protein synthesis during ontogeny sensitize distinct hematopoietic cell types to a ribosomal mutation in an age-dependent manner. cell.com/stem-cell-repo…

It has been a rough start to 2021, but congratulations Nick and co-authors showing that #BET proteins and #Mediator impact transcription without controlling enhancer-promoter interactions. Published in Nature Communications MRC WIMM MRC MHU
Full paper: rdcu.be/cdns5

Here is our latest work👩‍🔬👩‍💻 Forrester Lab @crm_edinburgh. Getting closer and closer to making HSCs in vitro from pluripotent stem cells! #StemCells #singlecellRNAseq #MachineLearning #HSCs

I just reported a set of 39 papers from a research group at Tianjin Medical University, all with overlapping images.

Here is a selection of the problems.

I’m thrilled to share a thread about our latest manuscript disclosing SR-0814, a potent inhibitor of ENL/AF9 YEATS domains, and SR-1114, a selective ENL PROTAC. We used these tools to provide the first pharmacological validation of ENL YEATS as a leukemia target. 1/19

I am excited to announce today that eLife - the journal is transitioning to a new model based on author-driven publishing (preprints) and public post-publication peer review and curation elifesciences.org/articles/64910…

My 1st, first-author #preprint ! A fun story on lineage priming and multipotency in #hematopoiesis Many thanks to my lab-mates in the Forsberg Lab and the awesome collaboration with my bay neighbor Roman E. Reggiardo in the Daniel Kim Lab! | IBSC_UCSC UC Santa Cruz Science UC Santa Cruz

I've been looking forward to see this in print. Congrats to all involved, really exciting work!

It is more than likely not worth your time to read my editorial, but I would highly encourage reading the many interesting MLL reviews that the editorial points toward Rob Klose andi roy MRC WIMM #KMT2A

AddThis | Home authors.elsevier.com/a/1c2OD6gJztxC…

Very proud to present my PhD work published Cell Stem Cell. A spatial profile of human blood development! Huge thanks to Alexander and the rest of the Medvinsky lab @crm_edinburgh and all other contributors. cell.com/cell-stem-cell…

For #FluorescenceFriday here is an magnificant cross section through a #salivarygland , with the saliva-producing acini in cyan and the saliva-transporting ducts in magenta, imaged this week by my hardworking #PhDstudent John Mckendrick #phdchat #AcademicChatter #academictwitter

Check out our #bioRxiv preprint, where we have used #proteomics to characterize lineage-biased hematopoietic progenitor cells in fetus and adult

Our latest paper is out Cell Stem Cell Single-Cell Analysis of Neonatal HSC Ontogeny Reveals Gradual and Uncoordinated Transcriptional Reprogramming that Begins before Birth cell.com/cell-stem-cell…

Looking forward to seeing all the research at ISEH 2020. Keep an eye out for contributions from the Ottersbach lab: Camille Malouf, Vasiliki and myself for our work on infant MLL-AF4 and MLL-AF9 acute leukaemias! ISEH