#Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual #Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage by Dan Hu, Ikuro Abe, and Hao Gao and co-workers in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Stereodivergent #photobiocatalytic radical cyclization via directed evolution of fatty acid photodecarboxylases by Ju, Li, Binh Khanh Mai, Liu, Alec Vallota-Eastman, Wu, Valentine, Peng Liu Group Pitt Chemistry, Yang Yang UCSB Department of Chemistry and Biochemistry in Nature Chemistry nature.com/articles/s4155…

#Engineering Peroxygenase Activity into #CytochromeP450 Monooxygenases through Modification of the Oxygen Binding Region by Matt Podgorski, Jinia Akter, Luke Churchman, John Bruning, James De Voss, Stephen Bell Stephen Bell Chemistry@Adelaide in ACS Catalysis pubs.acs.org/doi/10.1021/ac…

From Ground-State to Excited-State Activation Modes: #Flavin -Dependent “Ene”-Reductases Catalyzed Non-natural Radical Reactions by Haigen Fu and Todd K. Hyster Hyster Lab at Princeton Chemistry in ACS Publications Accounts of Chemical Research pubs.acs.org/doi/full/10.10…

Two Cytochrome P450 #Enzymes Form the Tricyclic Nested Skeleton of Meroterpenoids by Sequential Oxidative Reactions by E. Yang, Y. Yao, H. Su, Z. Sun, S.-S. Gao, S. Sureram, P. Kittakoop, K. Fan, Y. Pan, X. Xu, Z.-H. Sun, G. Ma, G. Liu in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Two Iron(II), α-Ketoglutarate-Dependent #Enzymes Encoded by the PPZ Gene Cluster of Metarhizium majus Enable Production of 8-Hydroxyperamine by Kristina W. Rothchild, Mostafa Hagar, Daniel Berry, and Katherine S. Ryan at UBC Chemistry in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

#Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis by Wesley Harrison, Guangde Jiang, Zhengyi Zhang, Maolin Li, Haoyu Chen, and Huimin Zhao Huimin Zhao at Chemistry at Illinois in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Concise #ChemoenzymaticSynthesis of 4,5-Dihydroxyisoleucine Fragment of α-Amanitin by Tsung-Han Chao, Hans Renata Hans Renata at Rice University Chemistry Department in ChemRxiv chemrxiv.org/engage/chemrxi…

#Asymmetric Synthesis of α-Chloroamides via #Photoenzymatic Hydroalkylation of Olefins by Yi Liu, Sophie Bender, Damien Sorigue, Daniel Diaz, Andrew Ellington, Greg Mann, Simon Allmendinger, and Todd Hyster Hyster Lab at Princeton Chemistry in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Radical SAM #Enzyme PylB Generates a Lysyl Radical Intermediate in the #Biosynthesis of Pyrrolysine by Using SAM as a Cofactor by Baixu Ma, R. David Britt at UC Davis Department of Chemistry, and Lizhi Tao in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products by Ye Wang, Katherine J. Torma, Joshua B. Pyser, Paul M. Zimmerman, and Alison Narayan Narayan Lab @ UMich at Michigan Chemistry in ACS Central Science pubs.acs.org/doi/10.1021/ac…

Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase #PolyketideSynthases by Xinyun Jian, Fang Pang, Christian Hobson, Matthew Jenner, Lona Alkhalaf, Challis Group in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

#Biosynthesis of Cytosporones in Leotiomycetous Filamentous Fungi by Li, Zhong, Liu, Espinosa-Artiles, Xu, Wang, Robles, Paz, Inácio, Chen, Xu, Gunatilaka, Molnár in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

I’m proud to share my first, first author publication, out now in ChemCatChem, An Overview of Syntheses of Salvinorin A and its Analogues! Check it out here: …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cc…

Two #SesterterpeneSynthases from Lentzea atacamensis Demonstrate the Role of Conformational Variability in Terpene #Biosynthesis by Binbin Gu, Bernd Goldfuss, and Jeroen S. Dickschat at Rheinische Friedrich-Wilhelms-Universität Bonn in Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

#Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable the Concise #ChemoenzymaticSynthesis of 9,10-Secosteroids by Hanxin Song, Zeliang Zhang, Chunyang Cao, Zhijun Tang, Gui Lab, and Wen Liu in Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

An intramolecular macrocyclase in plant #ribosomalpeptidebiosynthesis by Lisa Mydy, Jordan Hungerford, Desnor Chigumba Desnor Chigumba, Jamie Konwerski, Sarah Jantzi, Di Wang, Janet Smith, and Roland Kersten kersten lab at U-M Pharmacy in Nature Chemical Biology nature.com/articles/s4158…

#Biocatalytic strategy for the construction of sp3-rich polycyclic compounds by David Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia Borràs, Ken Houk at UCLA Chem & Biochem, and Rudi Fasan Fasan Lab at UT Dallas Chemistry in Nature Chemistry nature.com/articles/s4155…

Regiodivergent Radical Termination for Intermolecular #Biocatalytic C–C Bond Formation by Mark Petchey, Yuxuan Ye, Victor Spelling, James Finnigan, Samantha Gittings, Magnus Johansson, Martin Hayes AstraZeneca, Todd Hyster Lab Princeton Chemistry in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

Characterization and heterologous reconstitution of Taxus #biosyntheticenzymes leading to baccatin III in Science Magazine science.org/doi/10.1126/sc…