New paper from my group "Rollling circle synthesis catalyzed by RNA": elifesciences.org/articles/75186. Led by x.com/EmilLK2 and a great collaboration with x.com/ANoyLab in York. We show that RNA alone can catalyze all the steps of a viroid-like replication cycle.

We are looking for a postdoc at the MRC Laboratory of Molecular Biology, Cambridge, UK: nature.com/naturecareers/…. Candidates should have a strong background in molecular biology and technology development, ideally including in vitro evolution and machine learning. Please RT!

I was very pleased when Emil Kristoffersen and Phil Holliger approached me, wanting to know the structure of RNA mincircles as they undertake rolling circle amplification. Here is the result of our simulations, now published in eLife - the journal :

Happy to share our preprint based on an exciting collaboration with Phil Holliger. Thanks to the team for making it happen: Ewan McRae, Chris Wan, Emil Kristoffersen, Kalinka Hansen, Edoardo Gianni, @isaac_sur, Joe Curran and James Attwater. biorxiv.org/content/10.110…

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

New content online: Structure, folding and flexibility of co-transcriptional RNA origami dlvr.it/Sk5DHB

Check out the new results from Ebbe Sloth Andersen's group at iNANO - Interdisciplinary Nanoscience Center and Molekylærbiologi - Molecular Biology at Aarhus University and colleagues from Berkeley Lab

Det har faglige konsekvenser, når man reducerer uddannelser fra 2 til 1 år. Det skal #dkpol vide, når man laver så gennemgribende indgreb på #DKuni, som Regeringen lægger op til. Kristian Cedervall Lauta med vigtige input til Folketinget's Uddannelses- og Forskningsudvalg. #uddpol

The emergence of #life on Earth: LMU is launching the new Collaborative Research Centre TRR 392 “Molecular #Evolution in Prebiotic Environments”, funded by @dfg and founded on the research of @emergenceoflife. lmu.de/en/newsroom/ne…

Never expected to see this: #RNA on the (reverse) cover of the journal Proteins! Congrats to Rachael Kretsch and all authors of the #CASP15 special issue!

CryoEM unveils structure of nano-sized 'RNA copy machine,' a key player in the ancient RNA world. This breakthrough may fuel RNA nanotech and medical advancements. 🧬 Ebbe Sloth Andersen, Phil Holliger, and Ewan McRae et al. publish findings in PNAS (PNASNews). inano.au.dk/about/news-eve…

Our cryo-EM structure of an RNA polymerase ribozyme is now available in the databank with the PDB ID 8T2P: rcsb.org/3d-view/8T2P

Outreach talk at the Danish Science Festival in April: “Origin of Life in an RNA World” forsk.dk/indbakke/livet…

Nice news story about our recent research into the mythical RNA world, where we have explored the structure of the (proposed) central player: the RNA replicase. Thanks to Emil Kristoffersen, Ewan McRae, Phil Holliger and coauthors for making the research possible. sciencenews.dk/en/rna-researc…

4-year studentship available in my lab at King's Chemistry working at the interface of fundamental synthetic biology and therapeutic biotechnology development - come & join me in the XNA world! Please RT findaphd.com/phds/project/c…

New preprint from my lab, based on a great collaboration with Ebbe Sloth Andersen and Ewan McRae, Emil Kristoffersen.

We have submitted our second paper on the topic the RNA world in collaboration with Phil Holliger based on experimental work by Emil Kristoffersen and Ewan McRae in the Andersen Lab. Preprint is available on bioRxiv! Here comes a short explanation of the background and content.🧵1/7:

Read our latest story on the circles of life 😊