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Thrilled that our work linking oncogenic #mutations in #hsc to inflammatory #clonal neoplasms is out Nature Communications rdcu.be/cp3pa We discovered that #senescence drives bone marrow failure in a cell autonomous and #paracrine manner and identified #TNF as the main culprit!

Activating mutant BRAF in haematopoietic progenitors causes oncogene-induced senescence leading to myeloid restricted haematopoiesis, inflammation and histiocytosis in a murine model go.nature.com/3zvVmP3 #CancerResearch Raffaella Di Micco

I’m elated to be able to share our new story on p21 in Science Magazine! I feel very lucky to have been part of two wonderful institutions Mayo Clinic University of Groningen with fantastic collaborators! science.org/doi/10.1126/sc…

The best crew! Inspired by these talented people. A real privilege to work with them everyday! #BakhoumLab #AACR22 ⁦AACR⁩ ⁦Memorial Sloan Kettering Cancer Center⁩

Thrilled to announce I have been awarded with the Cancer Research Institute Irvington Fellowship to study tumor inflammation and immune response induced by Chromosomal Instability in Bakhoum Lab,Memorial Sloan Kettering Cancer Center. Thanks to Samuel Bakhoum,Raffaella Di Micco, Atif J Khan for supporting me

There is nothing for a PI more rewarding than seeing a past trainee (the very first trainee and PhD student of my lab!!) flourish in his postdoctoral journey Memorial Sloan Kettering Cancer Center! So well deserved Emanuele Lettera! I am really proud, looking forward to other great discoveries!🥳🥳🥳

Nothing better to do after a long @Twitter break than to congratulate the best of the best! Congrats Emanuele Lettera on this very well deserved honor and thank you Cancer Research Institute for the support and vote of confidence! #Cancer #Chromosomal_Instability

🔥 The latest from our lab, a key paper by Ines Marin in a project led by Manuel Serrano and Federico Pietrocola IRB Barcelona. Senescence is immunogenic and activates antitumor immunity. Collaboration with María Abad Alena Gros and more! aacrjournals.org/cancerdiscover…

1/ Our paper identifying #Chromosomal_Instability as a new driver of #epigenetic abnormalities in #cancer is out @nature nature.com/articles/s4158…

La scrittrice Michela Murgia è morta a Roma a 51 anni per un carcinoma renale al quarto stadio. Un estratto del suo intervento al Salone del Libro di Torino: "Io sto vivendo il tempo della mia vita adesso. Ma voi non aspettate di avere un cancro per fare così". #MichelaMurgia

Happy and honored to be part of this amazing work from Samuel Bakhoum lab and Ashley Laughney

Preprint alert! The trifecta of human aging studies have now all been released. Amazing collaboration with Raffaella Di Micco Serena Scala Emanuele Lettera. On Toronto side, it all started with Kena Flores, Kerstin Kaufmann and Laura GarciaPrat. biorxiv.org/content/10.110…

Here we are! First day of the #CICON23 conference, the best place to talk about #cancerimmunotherapy. We will present our poster “Therapeutic targeting STING-mediated tumor inflammation induced by Chromosomal Instability” Cancer Immunotherapy AACR Cancer Research Institute ENCI

Our first of a pair of reviews on #Chromosomal_Instability is out in ⁦NatureRevClinOncol⁩ on targeting CIN in patients with #cancer written with the amazing ⁦Duaa Al-Rawi, MD PhD⁩ ⁦Emanuele Lettera⁩ ⁦Jun Li⁩ ⁦Melody Di Bona⁩ nature.com/articles/s4157…

Celebrating the best team! Papers new arrivals and more! Very lucky to work with this group! #BakhoumLab #sciencetwitter

A new personalized vaccine is showing promising results in clinical trials in advanced clear cell renal cell cancer. Research by Toni Choueiri, MD, funded by #ConquerCancer, trains the immune system to attack any tumor cells leftover after surgery. brnw.ch/21wQS7V OncoAlert