Dual modes of #CRISPR-associated #transposon homing. Now online! bit.ly/3rr1Lqx

Beyond thrilled to finally share our work in Molecular Therapy: the first ever systematic analysis of the translational potential of chemogenetics. Would not have been possible without mike michaelides, Ruchit Patel, MSharif and AAshokan! bit.ly/3H4Kvjm cell.com/molecular-ther…

Excited to share the latest work from my PhD! We performed the first CRISPR activation screen to identify genes that drive solid tumor resistance to T cell-mediated cytotoxicity. A thread 1/X nature.com/articles/s4146…

We are looking for a motivated recent grad to join us as a lab technician! Perfect opportunity to gain more research experience for 2-3 years before applying to MD and/or PhD programs. Follow the link below to apply: 👉 tinyurl.com/WeissmanLabTech

Excited to share our work using a CRISPR-based lineage tracer to track tumor evolution from a single transformed cell to an aggressive tumor in a genetically engineered KP-Tracer model. It is a great collaboration of the Jonathan Weissman's Lab, Jacks Lab and Yosef Lab. cell.com/cell/fulltext/…

Our genome-scale Perturb-seq paper is out today in Cell! cell.com/cell/fulltext/… Cell Jonathan Weissman's Lab Thanks to all the authors and reviewers for their contributions. See the thread below for key findings.

Exciting work from my undergrad lab. Coral was an amazing mentor!

Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering Cell. We created a comprehensive TF ORF library and applied it to profile resulting expression changes. A thread 1/X sciencedirect.com/science/articl…

We are looking for a motivated recent grad (or soon-to-be grad) to join us as a lab technician! A great opportunity to gain research experience for 2-3 years before applying to MD and/or PhD programs. Apply here: shorturl.at/qruFU

Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemically competent MachOne (or other E. coli) cells, and Gibson assembly mix. Postdoc Julian Willis—who is starting his own lab in the UK soon—developed

On medRxiv today, we describe the plasma & CSF biomarker changes leading up to symptom onset in 4 cohort study participants who went on to develop active prion disease medrxiv.org/content/10.110…

Excited to share my first paper from grad school out today in Molecular Cell! We systematically define biogenesis pathways for alpha-helical OMM proteins triaged by the NAC and TTC1 chaperone complexes for polytopic and signal-anchored proteins (1/2). cell.com/molecular-cell…

.Jonathan Weissman's Lab and Broad Institute collaborators have developed a gene-silencing tool that shows promise as a therapy against fatal prion diseases. The tool, called CHARM, paves the way for a new class of genetic approaches to treat certain diseases: wi.mit.edu/news/charmed-c…

Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with Jonathan Weissman's Lab's Edwin Neumann & Tessa Bertozzi shows deep silencing of brain PrP Paper: science.org/doi/10.1126/sc… Blog: cureffi.org/2024/06/27/int…

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in Jonathan Weissman's Lab with Tessa Bertozzi and Elaine Wu science.org/doi/10.1126/sc…

We live in an age of (NIH-funded) biomedical miracles Within your lifetime, prion disease was considered potentially impossible to cure. Now there's a promising path towards one science.org/doi/10.1126/sc…