Dr. Robert Soiffer, our inspirational leader Dana-Farber, giving the honorific CIBMTR Mortimer Bortin lecture at #Tandem24 . So well deserved.

Thrilled to share our exciting #CART #singlecell data linking patient baseline immune characteristics with response to #axicel at #ASH2023 Satyen Gohil Izzy Roch Houot Dana-Farber

#ASH23 - Abstract 223
Outstanding presentation by Katie Maurer 👏🏻👏🏻👏🏻

Response to axi-cel is associated with:
✅The presence of > 0.5% circulating B-cells at baseline
✅Higher ALC/AMC at baseline
✅Enrichment of clonally expanded
CD8+ TEM cells in IP
#CARTcell

1/4 Excited to share #DIISCO 🪩, a Bayesian method for inferring cell-cell interactions over time in longitudinal #singlecell data 😱 DIISCO takes in cell type proportions and receptor-ligand expression and outputs cell state dynamics and cell-cell interaction networks! 🕺💃

This was a huge team and collaborative effort that spanned many institutions in the US and worldwide! Thank you to Emma Yin, Majzner_Lab Katie Maurer Katalin Danielne Sandor Bence Daniel Stephen Gottschalk MarieJosé Kersten St. Jude Dana-Farber Stanford University and our other co-authors! 8/n

Our paper about #azithromycin and post-alloHSCT relapse is published today in Blood Journal ! Happy to share the final version doi.org/10.1182/blood.… and the comment by Katie Maurer and Robert Soiffer doi.org/10.1182/blood.…. Laboratoire HIPI Saint-Louis Institut de Recherche Saint-Louis (IRSL) AP-HP Université Paris Cité

What a “harmless” antibiotic can teach us about GVL ashpublications.org/blood/article-…

Excited to share our recent paper in CHEST® Journal showing that in #intubated patients with #COVID19 , prolonged prone position ventilation (PPV) is associated with decreased #mortality and fewer pronation/supination events doi.org/10.1016/j.ches…

[1/6 🧵] Today Nature Medicine! Cellular dynamics monitored over time at the #SingleCell level reveals new insights into why some patients with large B cell lymphomas respond better than others to #CARTcell therapy rdcu.be/cVqVs

Read the main takeaways below 👇!

Today #AACR22 , don’t miss Nicholas Haradhvala presenting on single-cell analysis of cellular dynamics underlying clinical response to #CARTcell therapy in #collab work with Cathy Wu and Dr Marcela Maus labs (Talk #3575). Then, read more of the story @medrxiv: medrxiv.org/content/10.110…

With appropriate safeguards, the Dana-Farber Division of Stem Cell Transplantation and Cellular Therapies found cellular therapies can be safely administered throughout the ongoing #COVID19 pandemic: ms.spr.ly/6012pFPJg via Blood Advances #stemcells #CARTcelltherapy

Check in with Katie Maurer, MD, PhD, to learn about the Dana-Farber experience providing stem cell transplants during the first #COVID19 surge #TCTM21

👉 Poster #424: ms.spr.ly/6018pIj8E

The PARCHED study: ICU residents more likely to be oliguric than their patients. I couldn't agree more.
ncbi.nlm.nih.gov/pubmed/21156738