We saw the negative impact (psychologically and cognitively) of social isolation during the COVID pandemic. The ROI from socialization is increasingly being recognized on the epigenetic and other biological levels. Thanks for sharing this article Brandon Luu, MD June M

A good primer on the blood-brain-barrier cell.com/current-biolog…

📣 In 68K women in 🇺🇸 case-control studies in CARRIERS consortium: those w/ pathogenic mutation plus a 1st degree relative w/ #breastcancer had 23% risk of BC by age 50 & 51% risk from age 50-80 (vs 9% & 30% for those w/ just a mutation). Esp striking w/ PALB2. #bcsm #MedTwitter

I’m having an amazing time at the National Academies Annual (NAM) National Academies mtg in Washington, DC. today. AI is front and center as physician and nurse scientists discuss AI within the framework of healthcare in all its many facets June M

Cancer stem cells (CSC) are elusive and one of the reasons for resistance to treatment. Machine learning led to discovery of a way to promote their self-destruction (apoptosis) cell.com/cell-reports-m…

A 42-country analysis of change in cancer patterns with age indicates only colon cancer is clearly on the rise in the young (age 20-49 years). Most of the rest of 12 cancer types were increasing across the age groups. AAPC-average annual percentage change acpjournals.org/doi/10.7326/AN…

Many people ask me "Should I get a Galleri blood test for early cancer detection?" Here are the latest data erictopol.substack.com/p/the-largest-…

Outstanding DOM Grand Rounds Medical College of Wisconsin where Boston U Chobanian & Avedisian School of Medicine Dr Thomas Perls, Dir of the New England Centenarian Study and international leader in the field of human exceptional longevity is giving the Daniel Rudman Memorial Lecture on longevity June M

Congratulations to Lurie Cancer Center Dr Maha Hussain. Well done! June M

Fall is in full foliage.. creating a visually stunning landscape in beautiful Chicago ⁦June M⁩

Stunning Grand Rounds on “Exceptional Longevity: What’s it really like? Centenarians, their Kids, and How They Get There.” Delivered Medical College of Wisconsin by renowned GeroScientist Dr Thomas Perls Boston University an international leader in the field of human exceptional longevity June M

Immunotherapy has emerged as a new treatment for head and neck squamous cell carcinoma, but getting the immune system to attack certain tumors has been difficult. New discoveries made by MCW’s Dr. Joseph Zenga and his team could change that. Learn more: mcw.edu/mcwknowledge/m…

Happy Halloween MedX and all those who follow and support our work. It’s nice to decompress this evening with my wonderful clinical team June M

Wishing you a lovely time away June M

Congratulations Prof William Brady William J. Brady on being named a recipient of the 2025 Kabiller Science of Empathy Prize. As Dean Cornelli notes, this award advances “the understanding of empathy and celebrates Kellogg’s rigorous approach to the subject” June M

Such an incredible scientist and person. She eventually died by a blood disorder/malignancy caused by her exposure to her own discovery-radiation.

The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele? Encouraging results in the experimental model nature.com/articles/s4159… nature.com/articles/s4159…

A favorite read, I find myself revisiting time and time again David Steensma, MD - the loss of our patients is a hard part of oncology & it is important to take pride in caring so well for those who die ascopubs.org/doi/full/10.12…

Today in JAMA Oncology, we share new real-world evidence supporting reduced-dose EV + Pembro for 1st-line rx of advanced urothelial cancer (a dz of older adults) led by Penn Medicine - Abramson Cancer Center fellow Ryan Chow & Ronac Mamtani

We recently saw a randomized trial of exercise markedly improve cancer disease-free survival nejm.org/doi/full/10.10…. How can this be explained? sciencedirect.com/science/articl…