I'm thrilled to share our new study out in Nature Medicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the Tony Wyss-Coray lab. 🧵1/12 🔗 nature.com/articles/s4159…

Long-term study suggests that the more heatwaves people are exposed to, the more it accelerates body ageing. go.nature.com/4fTHsgt

Online Now: SKP1A bound to Polycomb-silenced genes mediates degradation of PRC2 and preconditions their activation dlvr.it/TMhmk0

A study in Nature Medicine identifies the Mediterranean diet as a promising approach to mitigate genetically dependent Alzheimer’s disease-related dementias risk by targeting a broad spectrum of metabolic pathways. go.nature.com/45Dwb0p

Very proud of this study that goes all the way from patients to🐟 and back! A fantastic example of how basic understanding of Zebrafish Rock! #lymphatics can help cure human diseases! Grateful for my team, especially Ivan Bassi, amazing collaborators and European Research Council (ERC) for support

Extremely delighted and humbled by the positive evaluation of our Vascular-Rhythm project. A great shoutout to my research team @ECAS_Mannheim, collaborators, mentors, and dear friends & family! Thank you! #ERCStG European Research Council (ERC)

Excited to share the first paper from my lab in nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s4158…

Our RAEFISH spatial transcriptomics technology is now published in Cell Cell! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

Human brain vascular multi-omics elucidates disease-risk associations. Read the full study led by Andrew C. Yang Gladstone Institutes UC San Francisco in Neuron #ASHG25 hubs.li/Q03NybYp0

The secret to the naked mole-rats’ extraordinarily long life may lie in subtle changes to just four amino acids, researchers report in Science. scim.ag/46SVkot

The Lipid Brain Atlas is out now! If you think lipids are boring and membranes are all the same, prepare to be surprised. Led by Luca Fusar Bassini with Gioele La Manno's lab, we mapped membrane lipids in the mouse brain at high resolution. biorxiv.org/cgi/content/sh…

Your cells (and not just the ones in your brain) remember. Fat cells retain an “obesogenic memory” after weight loss: an energetic imprint that primes them to store again. Viewed through the Energy Resistance Principle (ERP), this is a regulatory strategy for energy efficiency.

It’s been over 10 years since we began this journey with Christoph Maack exploring mitochondrial dysfunction in #AFib. Now we’ve reached an important milestone: Our work is out in Circulation Research! We show for the first time that impaired Ca²⁺ uptake into mitochondria is a hallmark of

As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science science.org/doi/10.1126/sc…

Nature research paper: A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization go.nature.com/477tvr7

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors go.nature.com/3Jc62gv

Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function dlvr.it/TNky2V

After decades of mystery, scientists at Gladstone identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice. nature UC San Francisco bit.ly/3WiGYrq

Selective RNA sequestration in biomolecular condensates directs cell fate transitions go.nature.com/3X215du

New OA Article: "RNA m6A regulates the transcription and heterochromatin state of retrotransposons in Arabidopsis" rdcu.be/eM95H m6A is recognized by nuclear readers CPSF30-L and ECT12, which associate with SUVH4/5/6 and ATXR5/6 to enhance histone methylation...