Deadly hyperinflammatory disease finds curative treatment from a repurposed drug!

DADA2, a rare hyperinflammatory condition, tragically forces children to endure strokes at a young age, often leading to premature death in their teenage years.

Without a single clinical trial,…

The impact of cytotoxic therapy on the risk of progression and death in clonal cytopenia(s) of undetermined significance ashpublications.org/bloodadvances/… #TCCUS Mayo Clinic Comprehensive Cancer Center

TET2 clonal hematopoiesis is enriched among individuals receiving solid organ transplantation. While this didn't predict transplant outcomes, whether it plays a role in the ultimate transplant indication requires further study aacrjournals.org/clincancerres/… AACR Alex Silver…

Rusfertide, a #Hepcidin Mimetic, for Control of Erythrocytosis in Polycythemia Vera | New England Journal of Medicine | ⁦NEJM⁩ | ⁦Marina Kremyanskaya, MD, PhD⁩ ⁦Andrew Kuykendall MD⁩ ⁦Naveen Pemmaraju, MD⁩ et al #MPNSM nejm.org/doi/full/10.10…

Just out in Nature Communications, our follow up study on the relevance of #HSC hierarchies in #venetoclax sensitivity by #MDSsm patients.
#collalab MD Anderson Cancer Center
🧵 below: nature.com/articles/s4146…

Our “Ahemolytic PNH letter” published; please consider PNH flow in cases of thrombosis and BMF even no signs of hemolysis. Thanks Ibrahim Ibrahim, M.D. Carmelo Gurnari Bhavisha Patel Waled Bahaj, MD Olisaemeka Ogbue, MD for your contributions. onlinelibrary.wiley.com/doi/10.1111/bj…

A study published today in the NEJM found that a blood test from Guardant Health searching for cell-free DNA from Colon Cancers detected 87% of cancers that were at an early and curable stage. The false positive rate was 10%.

nejm.org/doi/full/10.10…

IDH Mutant Myeloid Neoplasms are Associated with Seronegative Rheumatoid Arthritis and Innate Immune Activation. pubmed.ncbi.nlm.nih.gov/38457663/ Mayo Clinic Comprehensive Cancer Center Royal Adelaide Hospital #IDH #Rheumatology

If you think Mark Cuban and Common Sense Oncology should work together to bring cancer drug prices down, please RT us so that it gets Mark Cuban’s attention.

This is really, really exciting MD Anderson Cancer Center Hagop Kantarjian,MD

CD19 CAR T-cell transfer appeared to be feasible, safe, and efficacious in three different autoimmune diseases (SLE, idiopathic inflammatory myositis, systemic sclerosis) NEJM
nejm.org/doi/pdf/10.105…

Practical, lovely work: MD Anderson Cancer Center

Ivosidenib significantly reduces voriconazole and posaconazole levels when given concomitantly. 🎉 Proud of Ashley Dinh for all of her hard work! MD Anderson Cancer Center

acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn…

Delighted to contribute to this tour de force by A. Lin UCSF Cardiology, A. Bapat Mass General Heart, Patrick Ellinor Mass General Heart Broad Institute, & B. Ebert Dana-Farber Broad Institute using human genetics, murine models, & cell-based models to connect TET2 clonal…

Time to update my #clonal hematopoiesis slides! Two papers now online at #EHJ describe an association between @CHIP and cardiac arrythmias. Delighted to write the editorial comment with Domingo Pascual-Figal Marian Zuriaga: bit.ly/3whhO2D

Just so ya'll know, a group of physicians have been quietly making real progress on fixing prior authorization. Check out what's been happening in New Jersey. It's small, but it's something. 👇

Tina Shah STAT Nisha Mehta, MD Devika Bhushan, MD

“PATIENTS DON’T FAIL THERAPIES, THERAPIES FAIL PATIENTS!”

👉👉Exactly 10 yrs to the day, ibrutinib was approved for patients with relapsed CLL. This was the start of a paradigm shift in CLL Rx👏👏

👉👉BTKi remain one of the most effective drugs in CLL and now we are increasingly using 2nd gen and non covalent BTKi

It’s a landmark in the history of NASH (MASH)

A positive trial: less fibrosis, less inflammation, lower LDL

Something to celebrate

nej.md/4bHd7iT

#livertwitter

Time to move away from Dexamethasone for prevention of chemotherapy induced nausea and vomiting (CINV).

✅ Phase 3 double blind RCT
✅ DEX free prophylaxis is effective
✅ Lesser side effects like insomnia

ascopubs.org/doi/10.1200/GO…
JCO Global Oncology