Based on studies of male mice with acute stress the authors suggest NPYDRN/vlPAG neurons as a potential therapeutic target for stress-related disorders Nature Communications nature.com/articles/s4146…

More data from the EMERGE trial on use of #metformin #pregnancy Focus on SGA outcomes Diabetologia link.springer.com/article/10.100…

Preclinical studies characterize orally delivered glucose responsive #insulin polymers #diabetes Nature Nano nature.com/articles/s4156…

hPSC-derived VMI organoids proposed as a valuable tool for studying immune-cell-mediated host damage and uncovering the mechanism of β cell damage during viral exposure Cell Stem Cell #islets #diabetes cell.com/cell-stem-cell…

The GLP-1 receptor interactome in pancreatic β cell and neuronal cell lines nature.com/articles/s4158…

A new viewpoint from Rosen and Kajimura Journal of Clinical Investigation BIDMC "For now, however, we believe that the community should approach the notion that inflammation is the driver of #insulin resistance in humans as a hypothesis, rather than a proven fact" jci.org/articles/view/…?

Here the authors identify GLP-1 receptors in the mouse lateral septum as critical for the anorectic effects of liraglutide #weightloss Journal of Clinical Investigation jci.org/articles/view/…

A review of progress in cell replacement therapies for #T1D #diabetes #stemcells #islets Nature Reviews Endocrinology nature.com/articles/s4157…

How to assess the translational importance of the leaky gut Gastroenterology gastrojournal.org/article/S0016-…

We are only starting to comprehend potential differentiation of the new #weightloss drug mechanisms. An exciting time for new research with translational relevance Mariana Lenharo nature.com/articles/d4158… #obesity #T2D #Parkinsonsdisease #Alzheimersdisease

A new resource for keeping up to date in the #diabetes trial world

Macrophage metabolic memory-early intermittent feeding of mice with a high-cholesterol Western-type diet (WD) accelerates #atherosclerosis compared with late continuous exposure to WD with correlative data from human populations nature.com/articles/s4158…

Studies in mice identify roles for IL-1β-dependent neutrophil progenitor reprogramming in accelerated #atherosclerosis induced by alternating high fat diet exposure nature.com/articles/s4158…

Here it is proposed that CCL7 inhibition could be a therapeutic target for diabetic vasculopathy Science Translational Medicine #diabetes science.org/doi/10.1126/sc…

Based on associations and causal inference, the authors propose tailoring management of body composition based on inflammatory biomarkers with different glycaemic statuses dom-pubs.onlinelibrary.wiley.com/doi/10.1111/do…

Sortilin controls adipose tissue fatty acid oxidation by substrate fuel selection during beige fat activation and provides a potential targeted approach for the treatment of metabolic diseases #obesity Nature Communications nature.com/articles/s4146…

Here more evidence that central GHSR drives binge-like alcohol drinking independently of peripheral ghrelin nature.com/articles/s4138… molecularpsychiatry

Dorothy heads back to Kansas dejected on learning that a 4-week treatment with the widely used GLP-1 receptor agonist dulaglutide 1.5mg weekly had no effect on sexual desire, hypothalamic-pituitary-gonadal axis hormones or sperm parameters. Toto knew this thelancet.com/journals/ebiom…