Prof Rajiv Jalan: very glad to present the new Visiting Professor at Charité. Time to strengthen research translation and innovation.

2 years + 4 months into the project, A-TANGO has overcome tremendous challenges & is about to enroll its 1st patient into the #clinical G-TAK #study soon. At today's 5th Steering Committee (SC) Meeting, we realised how far we've come! #ACLF Prof Rajiv Jalan Cornelius Engelmann Eur. Fdn. for the Study of Chronic Liver Failure

Great symposium by experts in the field during last morning’s session of #EASLCongress : novelties in the therapeutic landscape for decompensated cirrhosis

✍🏽 Take home message: personalized and stratified treatment for patients with end-stage liver cirrhosis is highly warranted!

A-TANGO scientists host sessions & present their work @EASLCongress today + tomorrow: Come & listen to Annarein Kerbert from LUMC Leiden, Cornelius Engelmann from Charité - Universitätsmedizin Berlin & #EASL Secretary General Thomas Berg from Universitätsklinikum Leipzig!
European Liver Patients' Association #LiverTwitter #cirrhosis #ACLF

This episode of #EASLStudio is now available on demand
📺Watch: bit.ly/S4E14Video
🎧Listen: bit.ly/S4E14Podcast

@EASLNews
#LiverTwitter #ACLF

Find out from Prof Rajiv Jalan what #EASLStudio has in store for you this week!

📅Wednesday 12 April, 6pm CET
🔗easl.eu/easl-studio-ep…

Th B Rautou Pierre-Emmanuel Cornelius Engelmann Minneke Coenraad A-TANGO Decision4Liver MICROB-PREDICT

#LiverTwitter

Don't miss next week's #EASLStudio EASLnews with our Scientific Director Prof Rajiv Jalan, Decision4Liver coordinator Rautou Pierre-Emmanuel, A-TANGO clinical trial coordinator Cornelius Engelmann, and MICROB-PREDICT communication and dissemination WP leader Minneke Coenraad easl.eu/easl-studio-ep…

efclif.com/foundation/new…
What's the scientific basis for our new combinatorial treatment of acute-on-chronic liver failure ( #ACLF )? The #PressRelease by Eur. Fdn. for the Study of Chronic Liver Failure about the recently published study by Cornelius Engelmann et al. (@JHepatology) gives answers! #LiverTwitter European Liver Patients' Association

Our enterprise 'Fight #LiverFailure & #ACLF ' aka A-TANGO has entered the next phase! During yesterday's Steering Committee (SC) Meeting, we celebrated the successfully completed drug manufacturing process & got ready to initiate the #ClinicalTrial . Eur. Fdn. for the Study of Chronic Liver Failure European Liver Patients' Association EASLnews

Combination of TAK-242 & G-CSF
✅inhibits inflammation
✅promotes hepatic regeneration
✅prevents mortality
➡️in models of #ACuteOnChronicLiverFailure

❗️Potential treatment option for #ACLF

🔓 #OpenAccess at👉bit.ly/3zdoT36

Cornelius Engelmann
Prof Rajiv Jalan
#LiverTwitter

Save the date - The 4th Steering Committee (SC) Meeting takes place on Tuesday, 29 November 2022, online (via Zoom) from 9 am - 4 pm CET. Check your inbox for details. We are looking forward to seeing you all on-screen🙂! Prof Rajiv Jalan Cornelius Engelmann Daniel Green #ACLF #GTAK

Combination of TAK-242 & G-CSF
✅inhibits inflammation
✅promotes hepatic regeneration
✅prevents mortality
➡️in models of #ACuteOnChronicLiverFailure

❗️Potential treatment option for #ACLF

🔓 #OpenAccess at👉bit.ly/3zdoT36

Cornelius Engelmann
Prof Rajiv Jalan
#LiverTwitter

journal-of-hepatology.eu/article/S0168-…
Our Journal of Hepatology article by Cornelius Engelmann et al. highlights the scientific basis of A-TANGO & the therapeutic potential of the G-TAK #therapy for #ACLF . Recruitment starts in 2023! Eur. Fdn. for the Study of Chronic Liver Failure Prof Rajiv Jalan EASLnews Thomas Berg #LiverTwitter European Liver Patients' Association

youtu.be/7Gkdx86X_xw
'Will I develop alcoholic #hepatitis if I drink #alcohol ?' Patient representative Marinela Debu from European Liver Patients' Association interviews Dr. med. Cornelius Engelmann from Charité - Universitätsmedizin Berlin (supervisor of the clinical G-TAK trial) at #ILC2022 . EASLnews Prof Rajiv Jalan Eur. Fdn. for the Study of Chronic Liver Failure

The periportal zone of hepatic lobules
➡️essential role in emergence of #endotoxemia -associated #liverinjury

Reprogramming of #hepatocytes into a proinflammatory subpopulation
➡️key in endotoxemia-induced #immuneresponse

🔓 #OpenAccess at👉bit.ly/36nxYul

#LiverTwitter

#Hyperammonaemia in patients with #cirrhosis induces
➡️mitochondrial dysfunction
➡️overproduction of #ReactiveOxygenSpecies
➡️ #celldeath in primary neurons

🔓 #OpenAccess at👉bit.ly/3ntTC5k

Prof Rajiv Jalan
#LiverTwitter

🆕Article in press❕

Combination of G-CSF and a #TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of #ACLF

Read it here👉bit.ly/3zdoT36

Cornelius Engelmann
#LiverTwitter

Review article by S. Reichelt & Z. Czigany et al.“Body composition & the skeletal muscle compartment in liver transplantation: turning challenges into opportunities” doi.org/10.1111/ajt.17… Zoltan Czigany Georg Lurje🎗️ Cornelius Engelmann Charité - Universitätsmedizin Berlin Charité organ recovery unit HOPE-NMP ex-vivo machine perfusion trial RWTH Aachen