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Divergent transcription of the Nkx2-5 locus generates two enhancer RNAs with opposing functions sciencedirect.com/science/articl…

In aged mice treated with #Abatacept, which blocks #Tcell activation and #inflammation, #CardiacFunction was improved & #hearts displayed decreased #collagen deposition as well as #macrophage and #Tcell infiltration ow.ly/cqS830rbK3t Elisa Martini, PhD Marinos Kallikourdis, PhD

#Artery #coronarydisease: we are ready to fight! Through a complex analysis, we identified the epigenetic gene #DOT1L as a target of preventive and therapeutic approaches to #atherosclerosis. Check out our work: doi.org/10.1093/eurhea… European Society of Cardiology Journals EHJ Editor-in-Chief Humanitas Milano

#Research Letter: Autoimmunity in long-COVID-19 patients may cause cardiac dysfunction #AHAJournals ahajournals.org/doi/10.1161/CI…

Excited to share, out in Circulation, our study on autoimmunity in Post-COVID(aka #LongCOVID) cardiac symptoms. In short, we found that patients with post-COVID cardiac sequelae share an antibody response to autoantigens expressed in the heart, which was demonstrably cardiotoxic 1/x

I'm thrilled to be collaborating with Giacomo Rozzi Ph.D. in Cardiovascular Sciences at the Laboratory of Cardiovascular Medicine, led by @gcondorelli , as we observed cell kinematics during metabolic remodeling in cardiac aging under pseudohypoxia conditions. Paper published on Circulation Research ahajournals.org/doi/abs/10.116…

Circulation Research Sept 29th Issue is Out! ahajrnls.org/3wPOBJJ Cover: An integrative analysis of epigenomic, transcriptomic, & metabolic data has unveiled the significance of regulating enhancer activity in aging cardiomyocytes with p300/CBP playing a pivotal role in this process.

Serio et al found that epigenetically regulated modification of enhancer activity drives #metabolic changes in aging #cardiomyocytes, leading to decreased #CardiacFunction. Learn more at ahajrnls.org/3EXGmhX Christina Pagiatakis @gcondorelli Michele_Miragoli