Very excited to share SELMA, a computational method we developed for ATAC-seq & DNase-seq bias estimation, recently published in Nature Communications spearheaded by Shengen Shawn Hu w input from Cliff Meyer Lin Liu @guertinlab Ke Deng & Tingting Zhang nature.com/articles/s4146…

Are chromosomes memory machines? We just posted a bioRxiv with Jeremy Owen and Dino Osmanovic showing how 3D genome organization can help stabilize epigenetic information.

We are recruiting a Director of Translational Science at GV20 Therapeutics linkedin.com/jobs/view/3326…

Our work on Cistrome Explorer has been published! It lets you analyze thousands of chromatin profiles together with cell types, hierarchical clustering, and any other metadata, as well as information queried from Cistrome Data Browser doi.org/10.1093/bioinf… cisvis.gehlenborglab.org

1/ A reference cell tree will serve science better than a reference cell atlas buff.ly/3rxBm0h

Pleased to release TRUST4 v1.0.11 . The main feature is the direct AIRR-format VDJ annotation output from the "annotator" program. The stand-alone "annotator" could be used as a lightweight IgBLAST-like alternative. github.com/liulab-dfci/TR…

A short take on how computational approaches leverage multimodal single cell (RNA+ATAC) for inference of regulatory networks and a brief review of recent ground-breaking work by Dictys, SCENIC+ and MIRA by Luca Pinello @steinaerts Cistrome Data Browser et al. rdcu.be/disS3

.Cistrome Data Browser Dana-Farber Data Science disentangle technical and biological effects, facilitating batch-confounded chromatin and gene expression state discovery & enhancing the analysis of perturbation effects on cell populations. #BiotechNatureComms nature.com/articles/s4146…